151734

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 90562..91205 Replicon plasmid pEcoUTI1d
Accession NZ_CP049853
Organism Escherichia coli strain UPEC-774U/190308

Toxin (Protein)


Gene name vagD Uniprot ID C7S9Y5
Locus tag G9W34_RS24730 Protein ID WP_001034046.1
Coordinates 90789..91205 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID V0SR71
Locus tag G9W34_RS24725 Protein ID WP_001261278.1
Coordinates 90562..90792 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W34_RS24695 (G9W34_24630) 86073..86378 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
G9W34_RS24700 (G9W34_24635) 86380..86598 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
G9W34_RS24705 (G9W34_24640) 87165..87677 + 513 WP_000151784.1 hypothetical protein -
G9W34_RS24710 (G9W34_24645) 87711..88844 - 1134 WP_001542067.1 DUF3800 domain-containing protein -
G9W34_RS24715 (G9W34_24650) 89011..89784 - 774 WP_000905949.1 hypothetical protein -
G9W34_RS24720 (G9W34_24655) 89797..90297 - 501 WP_001773886.1 HEPN family nuclease -
G9W34_RS24725 (G9W34_24660) 90562..90792 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G9W34_RS24730 (G9W34_24665) 90789..91205 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin Toxin
G9W34_RS24735 (G9W34_24670) 91250..95044 - 3795 WP_001144732.1 hypothetical protein -
G9W34_RS24740 (G9W34_24675) 95425..95655 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin -
G9W34_RS24745 (G9W34_24680) 95652..96068 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id senB 1..102591 102591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14978.31 Da        Isoelectric Point: 6.7113

>T151734 WP_001034046.1 NZ_CP049853:90789-91205 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

>T151734 NZ_CP065692:c21038-20763 [Enterobacter asburiae]
ATGACCACAAGGACGATTGAATACTCAGGCCAGTTCCAGAAAGATGTGAAGAAGGCTCAGAAACGTCATAAAGACATGAG
CAAGCTTAAAGCCCTTATGACGCTGTTAATCAATGATGCCTTGCCATTGCCTCAAGTCTACAAAGATCACCCTCTACAGG
GGAACTACAAAGGCTATAGGGATGCTCACATAGAACCGGACTGGCTACTCATCTACAAGATAACTGATGAAGTCCTACGC
TTTGAGCGAACCGGAACACATTCAGACCTGTTTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8853.07 Da        Isoelectric Point: 4.6437

>AT151734 WP_001261278.1 NZ_CP049853:90562-90792 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPLRPSWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp

>AT151734 NZ_CP065692:c21302-21042 [Enterobacter asburiae]
ATGGCCGCAAATGCATTTGTTCGTGCTCGTATAGATGAAACACTGAAAAATGAAGCTGCAGTAGTGCTTGCCGGAATGGG
CTTAACCGTTTCCGATCTGGTTCGTATCACTCTGACTAAGGTAGCCAAAGAAAAGGCTCTGCCGTTCGATATGCGTGTTC
CTAATGAGCTTACTGCTAATACCATCGCTAACAGTGAGAAAGGCGTAGACGTTCATACAGCTAAAGATGCTGATGATCTG
TTTAATCAGCTTGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NXF9

Antitoxin

Source ID Structure
AlphaFold DB V0SR71

References