151729

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3651216..3651799 Replicon chromosome
Accession NZ_CP049852
Organism Escherichia coli strain UPEC-774U/190308

Toxin (Protein)


Gene name mazF Uniprot ID S1PVD8
Locus tag G9W34_RS17850 Protein ID WP_000254749.1
Coordinates 3651216..3651551 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag G9W34_RS17855 Protein ID WP_000581937.1
Coordinates 3651551..3651799 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W34_RS17835 (3647102) 3647102..3648400 - 1299 WP_000036723.1 phosphopyruvate hydratase -
G9W34_RS17840 (3648488) 3648488..3650125 - 1638 WP_001774030.1 CTP synthase (glutamine hydrolyzing) -
G9W34_RS17845 (3650353) 3650353..3651144 - 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
G9W34_RS17850 (3651216) 3651216..3651551 - 336 WP_000254749.1 endoribonuclease MazF Toxin
G9W34_RS17855 (3651551) 3651551..3651799 - 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
G9W34_RS17860 (3651877) 3651877..3654111 - 2235 WP_000226797.1 GTP diphosphokinase -
G9W34_RS17865 (3654159) 3654159..3655460 - 1302 WP_000046817.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12137.06 Da        Isoelectric Point: 8.7218

>T151729 WP_000254749.1 NZ_CP049852:c3651551-3651216 [Escherichia coli]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKR
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

>T151729 NZ_CP065688:3147515-3147904 [Serratia plymuthica]
ATGTATATGTTTGACACCAATACCGTGAGCCACCTGTTTCGCCGGCACCCAGGTTTGCTGAGTGCGATGGAAAAGGTGCC
GCCTTCCACCGTATGCATTTCCAGCATCACGGAGGCAGAGCTGCTTTTTGGCGTGGCCAAGCGGCAGAGTAAAGCGTTGA
AAGCCATGGTAACGGCGTTTTTAGCCGCGGTGACCGTTTATGACTGGGATAGCGAAGCTGCCCGCTGTTATGGCGTGATG
CGGGCGAGCATGGAGAAAAAAGGCAAAGTCCTGGGCGCGCTGGACCAGTTGATTGCCGCGCATGCGCTTAGCCGGGGCGC
GACAATGGTCACTAGCGATCGGGCCTTCGGCATGGTGTCCGGGCTGGACGTTGAAGACTGGACCCTATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT151729 WP_000581937.1 NZ_CP049852:c3651799-3651551 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp

>AT151729 NZ_CP065688:3147249-3147512 [Serratia plymuthica]
ATGGAAAGAATCGCAAAGCTGTTTAAAAATGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTCGAATTTGACACAGA
TCGCGTATATATCCGCCGCGATCGGGAGGGGAATGTGATTTTATCGAAATACCCTGCAAAACCGGACAGTTGGGAGCCGC
TGTTGAACATAATCGCCAAAACGCCGGTACCGCATGATTTTCTGGGCGCGGATGAACGCCAACAGGGCATTGCCGACCGG
GATCCTTTCGCAGAGGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PVD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LMB4

References