Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 315416..316248 Replicon chromosome
Accession NZ_CP049852
Organism Escherichia coli strain UPEC-774U/190308

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag G9W34_RS01425 Protein ID WP_000854753.1
Coordinates 315416..315790 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag G9W34_RS01430 Protein ID WP_001540478.1
Coordinates 315880..316248 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W34_RS01405 (311769) 311769..313307 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
G9W34_RS01410 (314056) 314056..314625 - 570 WP_001560692.1 DUF4942 domain-containing protein -
G9W34_RS01415 (314722) 314722..314919 - 198 WP_000839281.1 DUF957 domain-containing protein -
G9W34_RS01420 (314931) 314931..315419 - 489 WP_000777545.1 DUF5983 family protein -
G9W34_RS01425 (315416) 315416..315790 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
G9W34_RS01430 (315880) 315880..316248 - 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G9W34_RS01435 (316411) 316411..316632 - 222 WP_000692311.1 DUF987 domain-containing protein -
G9W34_RS01440 (316695) 316695..317171 - 477 WP_001186786.1 RadC family protein -
G9W34_RS01445 (317187) 317187..317672 - 486 WP_000214398.1 antirestriction protein -
G9W34_RS01450 (317763) 317763..318581 - 819 WP_001773857.1 DUF932 domain-containing protein -
G9W34_RS01455 (318671) 318671..318904 - 234 WP_001278283.1 DUF905 family protein -
G9W34_RS01460 (318910) 318910..319587 - 678 WP_001097301.1 hypothetical protein -
G9W34_RS01465 (319735) 319735..320415 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 303956..361274 57318


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T151707 WP_000854753.1 NZ_CP049852:c315790-315416 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T151707 NZ_CP065673:4072625-4072894 [Serratia plymuthica]
ATGCGGATAGAATGGAGTCGTGAAGCTCAGGAAGAGCTATGGAACATTATTGATTATATTGATGATAGAAACCCGCAGGC
GGCGCTCATTTTACAGCGCGAGATCGAAACGGCGGTGCATTCGCTGTCGCTGAATCCCTTTATGTACCGGTTGGGCAGAG
TAGATAACACTCGTGAGATTGTCGTCCATCCCAACTACCTGATTGTTTATAGAATCATCGGACATATAGAAGTTCTTGGC
GTGATTCACGCTAAACGAGAATATCCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT151707 WP_001540478.1 NZ_CP049852:c316248-315880 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT151707 NZ_CP065673:4072427-4072621 [Serratia plymuthica]
ATGGTGATCAAAACCTCCCTCTCCACCCAGCCCACAGCTGAGGTAGCCGAACAAGGCGAAAGTTACGATCGTTGGTTCCG
GGCCAAGATTGAAGCAGCCATTAACAGCGAAAAGCCAAGAATTCCGCACGAGCAGGTCATGAACGAGATGCAAATTCGTT
TAGCGGCGAAGAAAAAGATACGCAAAATGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References