Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1778..2337 Replicon plasmid pEcoUTI1f
Accession NZ_CP049846
Organism Escherichia coli strain UPEC-245U/190328

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G9W35_RS24430 Protein ID WP_001620845.1
Coordinates 2062..2337 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G9W35_RS24425 Protein ID WP_024188746.1
Coordinates 1778..2062 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W35_RS24420 (G9W35_24295) 1..873 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
G9W35_RS24425 (G9W35_24300) 1778..2062 + 285 WP_024188746.1 ribbon-helix-helix domain-containing protein Antitoxin
G9W35_RS24430 (G9W35_24305) 2062..2337 + 276 WP_001620845.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G9W35_RS24435 (G9W35_24310) 2447..2650 + 204 Protein_3 hypothetical protein -
G9W35_RS24440 2919..3185 - 267 WP_000627831.1 hypothetical protein -
G9W35_RS24445 3185..3403 - 219 Protein_5 hypothetical protein -
G9W35_RS24450 (G9W35_24315) 3431..4033 - 603 WP_000521606.1 ProQ/FINO family protein -
G9W35_RS24455 (G9W35_24320) 4209..5261 - 1053 WP_000655519.1 hypothetical protein -
G9W35_RS24460 (G9W35_24325) 5474..6064 - 591 WP_001401589.1 hypothetical protein -
G9W35_RS24465 (G9W35_24330) 6064..6318 - 255 WP_000343106.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA1 / ant(3'')-Ia / sul2 - 1..109478 109478


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10763.47 Da        Isoelectric Point: 9.9324

>T151699 WP_001620845.1 NZ_CP049846:2062-2337 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREIRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T151699 NZ_CP065673:1456518-1456721 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAACTAGAGCTGTTCTACTCTGCAGCGGACCACCGTTTGGCCGAGCTCACCATGAATAAGC
TTTACGATAAAATCCCCGTTGCCGTTTGGAAATTCGTACGATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10446.88 Da        Isoelectric Point: 5.6558

>AT151699 WP_024188746.1 NZ_CP049846:1778-2062 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAAKLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT151699 NZ_CP065673:1456099-1456467 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
AACACTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACACTGTTTAGCAGTTATGGTATTAATGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References