151697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 4714740..4715577 Replicon chromosome
Accession NZ_CP049845
Organism Escherichia coli strain UPEC-245U/190328

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag G9W35_RS22895 Protein ID WP_000227784.1
Coordinates 4715035..4715577 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag G9W35_RS22890 Protein ID WP_001297137.1
Coordinates 4714740..4715051 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W35_RS22865 (4709760) 4709760..4710707 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
G9W35_RS22870 (4710729) 4710729..4712720 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
G9W35_RS22875 (4712710) 4712710..4713324 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
G9W35_RS22880 (4713324) 4713324..4713653 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
G9W35_RS22885 (4713665) 4713665..4714555 + 891 WP_000971336.1 heme o synthase -
G9W35_RS22890 (4714740) 4714740..4715051 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
G9W35_RS22895 (4715035) 4715035..4715577 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
G9W35_RS22900 (4715633) 4715633..4716430 - 798 Protein_4478 tetratricopeptide repeat protein -
G9W35_RS22905 (4716531) 4716531..4717693 + 1163 WP_085947771.1 IS3-like element IS3 family transposase -
G9W35_RS22910 (4717725) 4717725..4717889 - 165 Protein_4480 sel1 repeat family protein -
G9W35_RS22915 (4718237) 4718237..4719601 + 1365 WP_001000974.1 MFS transporter -
G9W35_RS22920 (4719729) 4719729..4720220 - 492 WP_001138904.1 nucleotide binding protein YajQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T151697 WP_000227784.1 NZ_CP049845:4715035-4715577 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T151697 NZ_CP065673:c520472-520376 [Serratia plymuthica]
AACAAGCCCTGCACAAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT151697 WP_001297137.1 NZ_CP049845:4714740-4715051 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT151697 NZ_CP065673:520374-520516 [Serratia plymuthica]
ATAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTTTGTGCAGGGCTTGTTCAGCCATGCACTTTAAGAGTAGCTTACCGCGCTAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References