Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4680661..4681279 Replicon chromosome
Accession NZ_CP049845
Organism Escherichia coli strain UPEC-245U/190328

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G9W35_RS22725 Protein ID WP_001291435.1
Coordinates 4681061..4681279 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G9W35_RS22720 Protein ID WP_000344800.1
Coordinates 4680661..4681035 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W35_RS22710 (4675750) 4675750..4676943 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G9W35_RS22715 (4676966) 4676966..4680115 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
G9W35_RS22720 (4680661) 4680661..4681035 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G9W35_RS22725 (4681061) 4681061..4681279 + 219 WP_001291435.1 HHA domain-containing protein Toxin
G9W35_RS22730 (4681451) 4681451..4682002 + 552 WP_000102564.1 maltose O-acetyltransferase -
G9W35_RS22735 (4682118) 4682118..4682588 + 471 WP_000136192.1 YlaC family protein -
G9W35_RS22740 (4682752) 4682752..4684302 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G9W35_RS22745 (4684344) 4684344..4684697 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G9W35_RS22755 (4685076) 4685076..4685387 + 312 WP_000409911.1 MGMT family protein -
G9W35_RS22760 (4685418) 4685418..4685990 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151696 WP_001291435.1 NZ_CP049845:4681061-4681279 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T151696 NZ_CP065670:c2361835-2361560 [Sphingomonas paucimobilis]
ATGGCTCAAATAAGCTGGTCGGTTCAGGCCTCGCTCCAACTCGCCGCGATCGTCGATTATATAGAGCAGTTCGATCCCGA
CGCCGCCCGGCGCTTGGGTGACAGGCTGATCGACGTCGCCGAATCCTTGCGGCAATTCCCGGATCGCGGCAGGCCCATTT
CCCATGGCCGCCGCGAGATGGTGACGGTTCGCCCCTATGTCCTGCGCTATGAGCATGACGGCGAGACCGTCCTGATCCTC
GGCATTCGCCACGCCGCCCAACTTTCCGACGATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT151696 WP_000344800.1 NZ_CP049845:4680661-4681035 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT151696 NZ_CP065670:c2361984-2361823 [Sphingomonas paucimobilis]
ATTTTCGAGCAGCGTGACGAGGCGGCGGAACTGGCCGCCGACGAACGCGCACGGGCCGATTTCAAGGCGGGCCGTTTCGT
AAGCCATGAGAAGATGGCCGAATGGCTGAAGACCTGGGGCACCCCCGATCGCAAGCCCCTGCCCCCCGAATGGCTCAAAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References