Detailed information of TA system TA151694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3547761..3549349
• Replicon: chromosome
• Accession: NZ_CP049845
• Organism: Escherichia coli strain UPEC-245U/190328

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: G9W35_RS17235
• Protein ID: WP_001125463.1
• Coordinates: 3548027..3549349 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: G9W35_RS17230
• Protein ID: WP_001296726.1
• Coordinates: 3547761..3548027 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9W35_RS17230 (3547761)	3547761..3548027	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
G9W35_RS17235 (3548027)	3548027..3549349	+	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
G9W35_RS17240 (3549661)	3549661..3549869	+	209	Protein_3368	AraC family transcriptional regulator	-
G9W35_RS17245 (3550301)	3550301..3550864	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
G9W35_RS17250 (3551225)	3551225..3551935	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	3547761..3563851	16090

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T151694 WP_001125463.1 NZ_CP049845:3548027-3549349 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T151694 NZ_CP065668:c5188792-5188412 [Delftia acidovorans]
ATGAATCCCGTTCTGGTCGATACCTCGGTCTGGATCGATCACTTCAGGCAGGGCAATCCTCACCTGGCGCAGTTGCTGCA
GCAAGACATGGCGCTCATGCATCCCCTGGTGCTGGGTGAACTGGCTTGCGGCACGCCACCGGCACGCGCACGCACGCTCG
CGGACCTTCAGCGGCTCAAGCCTGCCCGACAGGCCAGCATGCGCGAAGTGCTGGCCTTGATAGAGCGCGAGCAACTCTTT
GGTCTGGGCTGCGGTCTGGTGGACATCACGCTCCTGGCCTCGGCACTCATGTCTTCAGGTGCCAGCCTGTGGTCGCGGGA
CAAGCGCCTGCACGCGCTGGCCCAGCGGTTTGGCATTGCCTACCGGAGCGTCTTGCCGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT151694 WP_001296726.1 NZ_CP049845:3547761-3548027 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT151694 NZ_CP065668:c5188992-5188789 [Delftia acidovorans]
ATGAGAACCACGGTCACCATCGACGACGCCTTGTACGAGGAAGCGCTGGAGCTGGCGGAGCCAGAAATGGACAAGGCCGA
CCTGTTTCGCGAAGCCATCAAGACTTTCGTGAGAGTGCAGGCGGCCAAGCGTCTGGCCGCGCTGGGAGGCTCCGCACCGG
ACATGCGGGAGATTCCCCGTCGCCCACAGGGCATCGAGCCATGA

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0