Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1836768..1837600 | Replicon | chromosome |
| Accession | NZ_CP049845 | ||
| Organism | Escherichia coli strain UPEC-245U/190328 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PD64 |
| Locus tag | G9W35_RS08835 | Protein ID | WP_000854753.1 |
| Coordinates | 1836768..1837142 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | V0ULY5 |
| Locus tag | G9W35_RS08840 | Protein ID | WP_001315620.1 |
| Coordinates | 1837232..1837600 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G9W35_RS08800 (1831835) | 1831835..1832440 | + | 606 | WP_021534527.1 | type II secretion system minor pseudopilin GspJ | - |
| G9W35_RS08805 (1832437) | 1832437..1833414 | + | 978 | WP_000633208.1 | type II secretion system minor pseudopilin GspK | - |
| G9W35_RS08810 (1833411) | 1833411..1834589 | + | 1179 | WP_000094963.1 | type II secretion system protein GspL | - |
| G9W35_RS08815 (1834591) | 1834591..1835127 | + | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| G9W35_RS08820 (1835408) | 1835408..1835977 | - | 570 | WP_001290247.1 | DUF4942 domain-containing protein | - |
| G9W35_RS08825 (1836074) | 1836074..1836271 | - | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| G9W35_RS08830 (1836283) | 1836283..1836771 | - | 489 | WP_000777547.1 | DUF5983 family protein | - |
| G9W35_RS08835 (1836768) | 1836768..1837142 | - | 375 | WP_000854753.1 | TA system toxin CbtA family protein | Toxin |
| G9W35_RS08840 (1837232) | 1837232..1837600 | - | 369 | WP_001315620.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| G9W35_RS08845 (1837763) | 1837763..1837984 | - | 222 | WP_238020674.1 | DUF987 domain-containing protein | - |
| G9W35_RS08850 (1838047) | 1838047..1838523 | - | 477 | WP_001560709.1 | RadC family protein | - |
| G9W35_RS08855 (1838539) | 1838539..1838718 | - | 180 | Protein_1723 | antirestriction protein | - |
| G9W35_RS08860 (1838802) | 1838802..1839206 | + | 405 | WP_000839179.1 | transposase | - |
| G9W35_RS08865 (1839203) | 1839203..1839550 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| G9W35_RS08870 (1839599) | 1839599..1841137 | + | 1539 | WP_221522814.1 | IS66-like element ISEc22 family transposase | - |
| G9W35_RS08875 (1841175) | 1841175..1841486 | - | 312 | Protein_1727 | antirestriction protein | - |
| G9W35_RS08880 (1841541) | 1841541..1842359 | - | 819 | WP_087893955.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14005.00 Da Isoelectric Point: 8.2905
>T151680 WP_000854753.1 NZ_CP049845:c1837142-1836768 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T151680 NZ_CP049845:c1837142-1836768 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13474.20 Da Isoelectric Point: 6.2050
>AT151680 WP_001315620.1 NZ_CP049845:c1837600-1837232 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT151680 NZ_CP049845:c1837600-1837232 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACTCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACTCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LVU0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0ULY5 |