Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1326961..1327592 Replicon chromosome
Accession NZ_CP049845
Organism Escherichia coli strain UPEC-245U/190328

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag G9W35_RS06265 Protein ID WP_001259385.1
Coordinates 1326961..1327236 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag G9W35_RS06270 Protein ID WP_000593555.1
Coordinates 1327233..1327592 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W35_RS06250 (1321979) 1321979..1323046 + 1068 WP_021565451.1 HlyD family secretion protein -
G9W35_RS06255 (1323043) 1323043..1325778 + 2736 WP_074499911.1 ribosome-associated ATPase/putative transporter RbbA -
G9W35_RS06260 (1325778) 1325778..1326902 + 1125 WP_021565453.1 ABC transporter permease -
G9W35_RS06265 (1326961) 1326961..1327236 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
G9W35_RS06270 (1327233) 1327233..1327592 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G9W35_RS06275 (1327642) 1327642..1328502 - 861 WP_001131788.1 class II aldolase -
G9W35_RS06280 (1328534) 1328534..1328803 - 270 WP_000933061.1 HPr family phosphocarrier protein -
G9W35_RS06285 (1328793) 1328793..1330301 - 1509 WP_021565454.1 FGGY-family carbohydrate kinase -
G9W35_RS06290 (1330294) 1330294..1331652 - 1359 WP_021565455.1 PTS galactitol transporter subunit IIC -
G9W35_RS06295 (1331729) 1331729..1332010 - 282 WP_000084025.1 PTS sugar transporter subunit IIB -
G9W35_RS06300 (1332007) 1332007..1332480 - 474 WP_001161650.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1311946..1327592 15646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T151678 WP_001259385.1 NZ_CP049845:1326961-1327236 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T151678 NZ_CP065656:612431-612610 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT151678 WP_000593555.1 NZ_CP049845:1327233-1327592 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT151678 NZ_CP065656:611808-612407 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References