Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 429987..430582 Replicon chromosome
Accession NZ_CP049845
Organism Escherichia coli strain UPEC-245U/190328

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag G9W35_RS02115 Protein ID WP_000239579.1
Coordinates 429987..430337 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag G9W35_RS02120 Protein ID WP_001223208.1
Coordinates 430331..430582 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W35_RS02095 (425263) 425263..426285 - 1023 WP_001296689.1 ABC transporter permease -
G9W35_RS02100 (426299) 426299..427801 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
G9W35_RS02105 (428111) 428111..429067 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
G9W35_RS02110 (429377) 429377..429907 + 531 WP_000055072.1 inorganic diphosphatase -
G9W35_RS02115 (429987) 429987..430337 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
G9W35_RS02120 (430331) 430331..430582 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
G9W35_RS02125 (430795) 430795..431136 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
G9W35_RS02130 (431139) 431139..434918 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T151675 WP_000239579.1 NZ_CP049845:c430337-429987 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T151675 NZ_CP065652:6781374-6781949 [Achromobacter xylosoxidans]
ATGAGGCATTCCCCCTTCACAGCCGTCTACGACGCATGCGTTTTGTATCCCGCGCCACTGCGGGACTTCCTGATGTGGCT
CGGCCTGTCCGGCCGCTTCAGGGCGCGGTGGAGTCAAGCCATCCATGAGGAGTGGAAACGCAACCTGTTGATCAAACGAC
CCGATCTCAACCGGGCGCAGGTCGACAGGACGTCCGATCTCATGGACAGGGCCATTCCGGACGGCGTGGTGGAGGGATAT
GAAGAGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGATCGGCACGTCCTGGCTGCGGCGATCCGCTGTGGTGCGAG
CGTGATCGTGACGTTCAACGAACGAGATTTCCCGAACGAGCTGCTGGCTGCGTACGGTATCGAAGCGCAGCACCCCGACG
AGTTCGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTCGTGTCAGCAGCGCAGCGCCAGCGTGCCCAGCTCAAGCAT
CCGCCAATCGACGTGGACTGCTTTCTCGAAATCCTGCTTCGCCAAGGCTTGGTGCAAACGACCAAAGTGCTGGCGACCTA
TCGCACCATCCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT151675 WP_001223208.1 NZ_CP049845:c430582-430331 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT151675 NZ_CP065652:6780907-6781377 [Achromobacter xylosoxidans]
ATGACCACCACCGCTGCCCAATCCAAGATGACCCTTCCCGCTGCGGCAGAGGTGAAGGCCGCCGTTCAGGGTCAACGTGC
CTTGGCGGCCTATCTGGCAACCCAGTTCGAGACGCAGCACATTCAGATCTTTGACGACCACAAGCAGGCGCATCAGGTGG
AGCTGCCCACCTCGGCTTTGCGCCTGCTTGTCGACATCCTGGCTGAACTGGCCGATGGCAACGCCGTGAAGGTGGTGCCC
GTTCACGCAGAGCTGACGACACAGGAGGCAGCCGATCTGCTCAACGTGTCCCGCCCCCATTTAGTCAAGCTGCTCGAGGA
TGGAGTGTTGGCATTTCACCGGACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References