Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 84362..85005 Replicon plasmid pEcoUTI1e
Accession NZ_CP049840
Organism Escherichia coli strain UPEC-455U/190220

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag G9W36_RS24730 Protein ID WP_001034044.1
Coordinates 84589..85005 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag G9W36_RS24725 Protein ID WP_001261286.1
Coordinates 84362..84592 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W36_RS24710 (G9W36_24655) 79499..79729 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
G9W36_RS24715 (G9W36_24660) 79726..80142 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
G9W36_RS24720 (G9W36_24665) 80187..83981 - 3795 WP_001144732.1 hypothetical protein -
G9W36_RS24725 (G9W36_24670) 84362..84592 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G9W36_RS24730 (G9W36_24675) 84589..85005 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
G9W36_RS24735 (G9W36_24680) 85080..86645 + 1566 WP_001128474.1 AAA family ATPase -
G9W36_RS24740 (G9W36_24685) 86630..87652 + 1023 WP_000361402.1 helicase UvrD -
G9W36_RS24750 (G9W36_24695) 88906..89603 + 698 WP_223369285.1 IS1-like element IS1A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) senB 1..91528 91528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T151669 WP_001034044.1 NZ_CP049840:84589-85005 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

>T151669 NZ_CP065650:297548-298285 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGATTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAGATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATGCAGCAGTATTTGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTTTAGATTCATATGGGGAAAAGATTGGGGCGAAGATT
GTTGTATTTGAAGCAGCAAAGGAATTAAATACAACCTTTCGCGGTATCCGCTCGCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTTATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT151669 WP_001261286.1 NZ_CP049840:84362-84592 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp

>AT151669 NZ_CP065650:298398-298523 [Bacillus cereus]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
GTTACAGCAAGTAGAAGAGTTAGAAGAAGAGTTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References