Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 79499..80142 Replicon plasmid pEcoUTI1e
Accession NZ_CP049840
Organism Escherichia coli strain UPEC-455U/190220

Toxin (Protein)


Gene name vagD Uniprot ID C7S9Y5
Locus tag G9W36_RS24715 Protein ID WP_001034046.1
Coordinates 79726..80142 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID V0SR71
Locus tag G9W36_RS24710 Protein ID WP_001261278.1
Coordinates 79499..79729 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W36_RS24680 (G9W36_24625) 75010..75315 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
G9W36_RS24685 (G9W36_24630) 75317..75535 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
G9W36_RS24690 (G9W36_24635) 76102..76614 + 513 WP_000151784.1 hypothetical protein -
G9W36_RS24695 (G9W36_24640) 76648..77781 - 1134 WP_001542067.1 DUF3800 domain-containing protein -
G9W36_RS24700 (G9W36_24645) 77948..78721 - 774 WP_000905949.1 hypothetical protein -
G9W36_RS24705 (G9W36_24650) 78734..79234 - 501 WP_001773886.1 HEPN family nuclease -
G9W36_RS24710 (G9W36_24655) 79499..79729 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G9W36_RS24715 (G9W36_24660) 79726..80142 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin Toxin
G9W36_RS24720 (G9W36_24665) 80187..83981 - 3795 WP_001144732.1 hypothetical protein -
G9W36_RS24725 (G9W36_24670) 84362..84592 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin -
G9W36_RS24730 (G9W36_24675) 84589..85005 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) senB 1..91528 91528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14978.31 Da        Isoelectric Point: 6.7113

>T151668 WP_001034046.1 NZ_CP049840:79726-80142 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

>T151668 NZ_CP065647:c4526965-4526615 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8853.07 Da        Isoelectric Point: 4.6437

>AT151668 WP_001261278.1 NZ_CP049840:79499-79729 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPLRPSWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp

>AT151668 NZ_CP065647:c4527251-4526970 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NXF9

Antitoxin

Source ID Structure
AlphaFold DB V0SR71

References