151663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3807017..3807671 Replicon chromosome
Accession NZ_CP049839
Organism Escherichia coli strain UPEC-455U/190220

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag G9W36_RS18470 Protein ID WP_000244781.1
Coordinates 3807017..3807424 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag G9W36_RS18475 Protein ID WP_000354046.1
Coordinates 3807405..3807671 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W36_RS18450 (3802974) 3802974..3804707 - 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -
G9W36_RS18455 (3804713) 3804713..3805423 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G9W36_RS18460 (3805448) 3805448..3806344 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G9W36_RS18465 (3806456) 3806456..3806977 + 522 WP_001055874.1 flavodoxin FldB -
G9W36_RS18470 (3807017) 3807017..3807424 - 408 WP_000244781.1 protein YgfX Toxin
G9W36_RS18475 (3807405) 3807405..3807671 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
G9W36_RS18480 (3807914) 3807914..3808894 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
G9W36_RS18485 (3808971) 3808971..3809630 - 660 WP_000250274.1 hemolysin III family protein -
G9W36_RS18490 (3809794) 3809794..3810105 - 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
G9W36_RS18495 (3810150) 3810150..3811583 + 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T151663 WP_000244781.1 NZ_CP049839:c3807424-3807017 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T151663 NZ_CP065640:c3968697-3968392 [Serratia rubidaea]
ATGCAGTTCCGCGTTTACACCTACCAGCGTGAGAGCCGCTACAGTCTGTTTGTGGATGTCCAGAGTGATATTATCGATAC
GCCCGGCCGGCGGATGGTTATCCCGCTGGTCAGCGCCCGGCAGCTGTCAGACAAGGTTCCGTATGAACTGTATCCGCTAG
TACAGATCGCCAATGAAAGCTACCGTCTGATGACGACGGAGATGGCCAGCGTTCCGGCTTCGGTAACCGGCGATGAAGTC
GCCGACCTCAGCCCGTGGGAGACGGAAATTAAGGATGCGATTAACCTGATGTTCTGGGGGATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT151663 WP_000354046.1 NZ_CP049839:c3807671-3807405 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT151663 NZ_CP065640:c3968917-3968699 [Serratia rubidaea]
ATGAAGCAGCGTATTACCGTGACGATCGACAGCGACAATTACCGGGTGCTTAAAGAGGCCGATGTGAATATATCCGGATT
GGTCAACAGGGCCATGCAGAATGAAGCCCGGCGTCTGCGTGCCGAACGCTGGCGTGCTGAAAATCGGGAGGGGATGGACG
AAGTGGCCCGCTTTATTGAAATGAATGGCTCGTTTGCTGACGAAAACCGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References