151662

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3651090..3651673 Replicon chromosome
Accession NZ_CP049839
Organism Escherichia coli strain UPEC-455U/190220

Toxin (Protein)


Gene name mazF Uniprot ID S1PVD8
Locus tag G9W36_RS17845 Protein ID WP_000254749.1
Coordinates 3651090..3651425 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag G9W36_RS17850 Protein ID WP_000581937.1
Coordinates 3651425..3651673 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W36_RS17830 (3646976) 3646976..3648274 - 1299 WP_000036723.1 phosphopyruvate hydratase -
G9W36_RS17835 (3648362) 3648362..3649999 - 1638 WP_001774030.1 CTP synthase (glutamine hydrolyzing) -
G9W36_RS17840 (3650227) 3650227..3651018 - 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
G9W36_RS17845 (3651090) 3651090..3651425 - 336 WP_000254749.1 endoribonuclease MazF Toxin
G9W36_RS17850 (3651425) 3651425..3651673 - 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
G9W36_RS17855 (3651751) 3651751..3653985 - 2235 WP_000226797.1 GTP diphosphokinase -
G9W36_RS17860 (3654033) 3654033..3655334 - 1302 WP_000046817.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12137.06 Da        Isoelectric Point: 8.7218

>T151662 WP_000254749.1 NZ_CP049839:c3651425-3651090 [Escherichia coli]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKR
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

>T151662 NZ_CP065640:c2639737-2639534 [Serratia rubidaea]
ATGACAAAAACCGACTACCTGATGCGTTTACGTAAATGCACCACTATCGATACGCTTGAAAGAGTGATTGAAAAAAACAA
GTACGCGCTCTCTGACGATGAGCTCGAGCTGTTTTACTCCGCAGCCGACCACCGTCTGGCTGAACTCACCATGAATAAGC
TGTATGACAAAATCCCGACGTCTGTTTGGAAATATGTAAGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT151662 WP_000581937.1 NZ_CP049839:c3651673-3651425 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp

>AT151662 NZ_CP065640:c2640165-2639797 [Serratia rubidaea]
ATGGATGAGTACTCGCCGAAACGGCATGATATTGCTCAACTCAAATTCTTGTGTGAAAATCTGTACGATGAAGGCATTGC
GACGTTGGGCGACAGCCATCACGGCTGGGTTAACGATCCGACTTCGGCCGTCAATCTGCAGCTGAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATAAAATACATGGACGAAAGTGACTTTTCAGAATTAGTCGAAGAGTACCTC
GACGATACCTATACGTTATTTAGTAACTACGGTATTAACGATTCCGATCTGCGTCGTTGGCAAAAAACTAAACGGCGACT
ATTCAGAATGTTCTCAGGAGAGGTTTGCTGTACGAAAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PVD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LMB4

References