Detailed information of TA system TA151638

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 4085072..4085637
• Replicon: chromosome
• Accession: NZ_CP049838
• Organism: Streptomyces cacaoi subsp. asoensis strain H2S5

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: G9272_RS18225
• Protein ID: WP_171397571.1
• Coordinates: 4085072..4085440 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: G9272_RS18230
• Protein ID: WP_171397572.1
• Coordinates: 4085440..4085637 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9272_RS18205	4080214..4081185	+	972	WP_171397569.1	glycine betaine ABC transporter substrate-binding protein	-
G9272_RS18210	4081232..4082023	-	792	WP_171397570.1	hypothetical protein	-
G9272_RS18215	4082156..4082806	-	651	WP_020132430.1	helix-turn-helix domain-containing protein	-
G9272_RS18220	4083134..4084936	-	1803	WP_054240231.1	DEAD/DEAH box helicase	-
G9272_RS18225	4085072..4085440	-	369	WP_171397571.1	Fic family protein	Toxin
G9272_RS18230	4085440..4085637	-	198	WP_171397572.1	hypothetical protein	Antitoxin
G9272_RS18235	4085670..4087142	-	1473	WP_171397573.1	MFS transporter	-
G9272_RS18245	4087647..4088150	-	504	WP_171397574.1	hypothetical protein	-
G9272_RS18250	4088147..4088977	-	831	WP_171397575.1	GTPase domain-containing protein	-
G9272_RS18255	4089159..4089566	-	408	WP_171397576.1	hypothetical protein	-
G9272_RS18260	4089736..4090527	-	792	WP_171397577.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (4-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13781.66 Da
• Isoelectric Point: 5.5372

>T151638 WP_171397571.1 NZ_CP049838:c4085440-4085072 [Streptomyces cacaoi subsp. asoensis]
MHHLTLDELLNLTRRLGADEVRDYGLLDSALARPRSSVFGQDAYPDVWRKAAALMESLARNHGLVDGNKRIAWYATWVFL
HLDGHPLDVDFDVDEAERFVLDVCQGVLDVPGIAARLPRFAR

Nucleotide

• Length: 369 bp

>T151638 NZ_CP065624:c4292836-4292729 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7275.12 Da
• Isoelectric Point: 5.0632

>AT151638 WP_171397572.1 NZ_CP049838:c4085637-4085440 [Streptomyces cacaoi subsp. asoensis]
MAGLNLRFTDEELDALRERAQAEGRSMQAFAHDAVIKAVNEHARLFEEAAEHVLNASAELNRRLA

Nucleotide

• Length: 198 bp

>AT151638 NZ_CP065624:4292883-4292949 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT