151636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2671499..2672061 Replicon chromosome
Accession NZ_CP049836
Organism Gordonia terrae strain RL-JC02

Toxin (Protein)


Gene name relE Uniprot ID A0A6G7W718
Locus tag G8C36_RS11665 Protein ID WP_055477308.1
Coordinates 2671771..2672061 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6G7W6R5
Locus tag G8C36_RS11660 Protein ID WP_055477309.1
Coordinates 2671499..2671774 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8C36_RS11630 2667187..2668125 + 939 WP_083207430.1 RNA polymerase sigma-70 factor -
G8C36_RS11635 2668274..2668654 + 381 WP_065631666.1 SRPBCC family protein -
G8C36_RS11640 2668706..2669011 - 306 WP_068970442.1 hypothetical protein -
G8C36_RS11645 2669066..2669827 - 762 WP_068970441.1 hypothetical protein -
G8C36_RS11650 2670235..2670762 + 528 WP_065631669.1 GNAT family N-acetyltransferase -
G8C36_RS11655 2670780..2671379 + 600 WP_065631677.1 TetR/AcrR family transcriptional regulator -
G8C36_RS11660 2671499..2671774 + 276 WP_055477309.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G8C36_RS11665 2671771..2672061 + 291 WP_055477308.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8C36_RS11670 2672080..2672286 - 207 WP_055477311.1 hypothetical protein -
G8C36_RS11675 2672954..2673187 - 234 WP_055477307.1 hypothetical protein -
G8C36_RS11680 2673776..2674015 - 240 WP_055477305.1 hypothetical protein -
G8C36_RS11685 2674050..2676110 - 2061 WP_068970440.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-94)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10938.40 Da        Isoelectric Point: 9.7360

>T151636 WP_055477308.1 NZ_CP049836:2671771-2672061 [Gordonia terrae]
MSDAPTDSSAPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAENPHRLSKPLRDDLADLHSARRGDYRILLRIDDPNH
TIVIVRIDHRAHAYRT

Download         Length: 291 bp

>T151636 NZ_CP065624:c3524800-3524582 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9718.86 Da        Isoelectric Point: 4.3809

>AT151636 WP_055477309.1 NZ_CP049836:2671499-2671774 [Gordonia terrae]
MTTVPLGEAKDKLSALVDSAESTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGVRDDVATADAEYAAGETVSID
DLRAEHGMPPK

Download         Length: 276 bp

>AT151636 NZ_CP065624:c3525200-3524826 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G7W718

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7W6R5

References