Detailed information of TA system TA151635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 1027063..1028018
• Replicon: chromosome
• Accession: NZ_CP049836
• Organism: Gordonia terrae strain RL-JC02

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: G8C36_RS04520
• Protein ID: WP_165629536.1
• Coordinates: 1027443..1028018 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: G8C36_RS04515
• Protein ID: WP_165629535.1
• Coordinates: 1027063..1027446 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G8C36_RS04490	1022213..1023106	-	894	WP_165629532.1	acetaldehyde dehydrogenase (acetylating)	-
G8C36_RS04495	1023353..1024441	+	1089	WP_165629533.1	VOC family protein	-
G8C36_RS04500	1024520..1025743	+	1224	WP_165630783.1	acyl-CoA dehydrogenase family protein	-
G8C36_RS04505	1025900..1026394	+	495	WP_165629534.1	peptide-methionine (R)-S-oxide reductase MsrB	-
G8C36_RS04510	1026391..1026939	+	549	WP_068970820.1	peptide-methionine (S)-S-oxide reductase MsrA	-
G8C36_RS04515	1027063..1027446	+	384	WP_165629535.1	hypothetical protein	Antitoxin
G8C36_RS04520	1027443..1028018	+	576	WP_165629536.1	zeta toxin family protein	Toxin
G8C36_RS04525	1028015..1028962	+	948	WP_165629537.1	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	-
G8C36_RS04530	1028987..1029619	-	633	WP_165629538.1	flavin reductase family protein	-
G8C36_RS04535	1029712..1030443	+	732	WP_078113769.1	tyrosine-protein phosphatase	-
G8C36_RS04540	1030436..1030753	+	318	WP_165629539.1	DUF2470 domain-containing protein	-
G8C36_RS04545	1030757..1031800	-	1044	WP_165629540.1	LacI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (2-121)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-68)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21176.30 Da
• Isoelectric Point: 10.1705

>T151635 WP_165629536.1 NZ_CP049836:1027443-1028018 [Gordonia terrae]
VTPRLDLVVGCNGAGKSTLVERHLQPLLHVPFVNADLIARQRWPDSAEAHSYDAARLAAATRDTLIERGTSFIAETVFSH
PSKLELIERAHTAGYRVALHVVMIPEALAVHRVRLRVDSGGHAVAEVKIRERFRRLWPLVRTAIARSDLATVYANERPTT
RIVARYVDGLVAGVPDWPDWTPGALTDTKAR

Nucleotide

• Length: 576 bp

>T151635 NZ_CP065624:c3488744-3488202 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 13669.10 Da
• Isoelectric Point: 5.2284

>AT151635 WP_165629535.1 NZ_CP049836:1027063-1027446 [Gordonia terrae]
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRQRVEAALAGDLPGDVLTAEEAVVYDAEI
DAHLEARLATDDHVVRRASAGLSSVVVDDAGRLVEHRPDGTSVILEQ

Nucleotide

• Length: 384 bp

>AT151635 NZ_CP065624:c3489039-3488728 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCACCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA