151633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 10277..11630 Replicon plasmid pB
Accession NZ_CP049832
Organism Aeromonas salmonicida subsp. masoucida strain RZ6S-1

Toxin (Protein)


Gene name sanaT Uniprot ID A0A807ZF23
Locus tag G9H43_RS24065 Protein ID WP_042468256.1
Coordinates 10277..11242 (-) Length 322 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A807ZF76
Locus tag G9H43_RS24070 Protein ID WP_042468273.1
Coordinates 11232..11630 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9H43_RS24030 (G9H43_24155) 5979..6206 + 228 WP_225854524.1 hypothetical protein -
G9H43_RS24035 (G9H43_24160) 6989..7300 + 312 WP_042468251.1 helix-turn-helix transcriptional regulator -
G9H43_RS24040 (G9H43_24165) 7332..8237 + 906 WP_157668949.1 reverse transcriptase family protein -
G9H43_RS24045 (G9H43_24170) 8343..8525 - 183 WP_042468252.1 hypothetical protein -
G9H43_RS24050 (G9H43_24175) 8690..8842 - 153 WP_042468253.1 Hok/Gef family protein -
G9H43_RS24055 (G9H43_24180) 9350..9847 - 498 WP_042468254.1 hypothetical protein -
G9H43_RS24060 (G9H43_24185) 9866..10180 - 315 WP_225854525.1 hypothetical protein -
G9H43_RS24065 (G9H43_24190) 10277..11242 - 966 WP_042468256.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
G9H43_RS24070 (G9H43_24195) 11232..11630 - 399 WP_042468273.1 DUF6088 family protein Antitoxin
G9H43_RS24075 (G9H43_24200) 12567..13013 + 447 WP_042468257.1 DNA repair protein RadC -
G9H43_RS24080 (G9H43_24205) 13053..13415 + 363 WP_042468258.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..70939 70939


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-302)

Antitoxin

Protein of unknown function DUF6088

(7-128)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 36419.60 Da        Isoelectric Point: 5.4150

>T151633 WP_042468256.1 NZ_CP049832:c11242-10277 [Aeromonas salmonicida subsp. masoucida]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHSCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVICRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHKL
I

Download         Length: 966 bp

>T151633 NZ_CP065624:c2993026-2992874 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14761.36 Da        Isoelectric Point: 11.0142

>AT151633 WP_042468273.1 NZ_CP049832:c11630-11232 [Aeromonas salmonicida subsp. masoucida]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA

Download         Length: 399 bp

>AT151633 NZ_CP065624:2993075-2993132 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ZF23

Antitoxin

Source ID Structure
AlphaFold DB A0A807ZF76

References