Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 160828..162396 Replicon plasmid pA
Accession NZ_CP049831
Organism Aeromonas salmonicida subsp. masoucida strain RZ6S-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag G9H43_RS23445 Protein ID WP_128313846.1
Coordinates 161089..162396 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag G9H43_RS23440 Protein ID WP_219934974.1
Coordinates 160828..161079 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9H43_RS23410 (G9H43_23500) 155903..156733 - 831 WP_232048272.1 hypothetical protein -
G9H43_RS23415 (G9H43_23505) 156745..157386 - 642 WP_219934972.1 hypothetical protein -
G9H43_RS23420 (G9H43_23510) 157734..158264 + 531 WP_128313844.1 hypothetical protein -
G9H43_RS23425 (G9H43_23515) 158267..159271 + 1005 WP_219934973.1 tyrosine-type recombinase/integrase -
G9H43_RS23430 (G9H43_23520) 159493..159672 + 180 WP_128313842.1 hypothetical protein -
G9H43_RS23435 (G9H43_23525) 159741..160190 + 450 WP_128313841.1 hypothetical protein -
G9H43_RS23440 (G9H43_23530) 160828..161079 + 252 WP_219934974.1 helix-turn-helix domain-containing protein Antitoxin
G9H43_RS23445 (G9H43_23535) 161089..162396 + 1308 WP_128313846.1 type II toxin-antitoxin system HipA family toxin Toxin
G9H43_RS23450 (G9H43_23540) 162393..162887 + 495 WP_128313839.1 hypothetical protein -
G9H43_RS23455 (G9H43_23545) 163210..163455 - 246 WP_128313837.1 hypothetical protein -
G9H43_RS23460 (G9H43_23550) 163656..165242 + 1587 WP_128313836.1 DUF2235 domain-containing protein -
G9H43_RS23465 (G9H43_23555) 165247..165531 + 285 WP_234915199.1 hypothetical protein -
G9H43_RS23470 165573..165959 + 387 WP_219934975.1 hypothetical protein -
G9H43_RS23475 (G9H43_23565) 166646..166861 + 216 WP_034168403.1 DUF2158 domain-containing protein -
G9H43_RS23480 (G9H43_23570) 166864..167130 + 267 WP_258236872.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / aac(6')-Ib-cr / blaOXA-1 / catB3 / catA2 / ARR-3 / qacE / sul1 / floR / formA - 1..286000 286000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 47845.08 Da        Isoelectric Point: 6.2421

>T151632 WP_128313846.1 NZ_CP049831:161089-162396 [Aeromonas salmonicida subsp. masoucida]
MQTLTVAMNGEVVGTLYRDNKGAMSFQYAPEWISEPGSRAISMSLPLGHGRITGSEVFNFFSNLLPDSEAIIARMQARFR
VETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDEAQIELLLEGYQEAPLGMAEDADFRISIAGAQEKTALL
WYQDCWQRPLGSTPTSHIFKLPIGRIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKKKVLVVQRFDRRWSKS
GEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEPAS
SFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYHFAMIQPRHFISTAAHVGFPQDTAAQLMLEMATKTEAVVA
TVAAELPAGFPEHISNAIFDGLSSQAAKILKGVAK

Download         Length: 1308 bp

>T151632 NZ_CP065624:2397262-2397573 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9411.83 Da        Isoelectric Point: 9.9484

>AT151632 WP_219934974.1 NZ_CP049831:160828-161079 [Aeromonas salmonicida subsp. masoucida]
MRVTSPTLLAAAVRDQRKISKLTQSEAAKQVGIKQTTVSDFELRPESTKLETLFKLLSALDLELHVVKRGSTLDDSKVWD
REW

Download         Length: 252 bp

>AT151632 NZ_CP065624:2397574-2397864 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References