Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 498068..498708 | Replicon | chromosome |
| Accession | NZ_CP049830 | ||
| Organism | Aeromonas salmonicida subsp. masoucida strain RZ6S-1 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A807Z4U5 |
| Locus tag | G9H43_RS02450 | Protein ID | WP_005320982.1 |
| Coordinates | 498068..498481 (-) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A807Z5T0 |
| Locus tag | G9H43_RS02455 | Protein ID | WP_005320985.1 |
| Coordinates | 498478..498708 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G9H43_RS02425 (G9H43_02435) | 494440..495060 | + | 621 | WP_232484104.1 | subclass B2 metallo-beta-lactamase | - |
| G9H43_RS02430 (G9H43_02440) | 495208..496125 | + | 918 | WP_088814123.1 | IS5-like element ISAs4 family transposase | - |
| G9H43_RS02435 (G9H43_02445) | 496360..497277 | + | 918 | WP_076611341.1 | IS5-like element ISAs4 family transposase | - |
| G9H43_RS02440 (G9H43_02450) | 497281..497601 | - | 321 | WP_232479382.1 | hypothetical protein | - |
| G9H43_RS02445 (G9H43_02455) | 497637..497990 | - | 354 | WP_017413138.1 | hypothetical protein | - |
| G9H43_RS02450 (G9H43_02460) | 498068..498481 | - | 414 | WP_005320982.1 | PIN domain-containing protein | Toxin |
| G9H43_RS02455 (G9H43_02465) | 498478..498708 | - | 231 | WP_005320985.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| G9H43_RS02460 (G9H43_02470) | 498777..499082 | - | 306 | WP_225854310.1 | integrase | - |
| G9H43_RS02465 (G9H43_02475) | 499076..499465 | - | 390 | WP_139403308.1 | site-specific integrase | - |
| G9H43_RS02470 (G9H43_02485) | 499882..500799 | - | 918 | WP_076611341.1 | IS5-like element ISAs4 family transposase | - |
| G9H43_RS02475 (G9H43_02490) | 500867..501268 | + | 402 | Protein_465 | IS4 family transposase | - |
| G9H43_RS02480 (G9H43_02495) | 501341..502732 | - | 1392 | WP_034283822.1 | T3SS effector protein-tyrosine-phosphatase AopH | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | aopH / aerA/act | 495208..512920 | 17712 | |
| - | inside | IScluster/Tn | - | aopH | 492972..512358 | 19386 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 14935.23 Da Isoelectric Point: 5.7146
>T151630 WP_005320982.1 NZ_CP049830:c498481-498068 [Aeromonas salmonicida subsp. masoucida]
VKTFMLDTCICSFIMREMPQSVLERLGAEVASGNRIVISAITYAEMRYGQIGKKASPKLGPAIDEFVRRLDGILPWDAAT
VDQTLEVRQQLAALGTPIGNNDAAIAAHALTAGCVLVTNNTREFSRVAGLLYEDWVH
VKTFMLDTCICSFIMREMPQSVLERLGAEVASGNRIVISAITYAEMRYGQIGKKASPKLGPAIDEFVRRLDGILPWDAAT
VDQTLEVRQQLAALGTPIGNNDAAIAAHALTAGCVLVTNNTREFSRVAGLLYEDWVH
Download Length: 414 bp
>T151630 NZ_CP065624:1608472-1608936 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAAACCATTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8699.88 Da Isoelectric Point: 4.7419
>AT151630 WP_005320985.1 NZ_CP049830:c498708-498478 [Aeromonas salmonicida subsp. masoucida]
MRTVSIFKNGKNQAVRLPKDMEFQGVNDLEIIKNGDTITLRPARPDWFSLAECQKVDADFLQERTDVISDEGRFAL
MRTVSIFKNGKNQAVRLPKDMEFQGVNDLEIIKNGDTITLRPARPDWFSLAECQKVDADFLQERTDVISDEGRFAL
Download Length: 231 bp
>AT151630 NZ_CP065624:1608137-1608472 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A807Z4U5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A807Z5T0 |