Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4006744..4007398 Replicon chromosome
Accession NZ_CP049828
Organism Janthinobacterium lividum strain EIF2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G8765_RS18340 Protein ID WP_176386214.1
Coordinates 4006744..4006920 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G8765_RS18345 Protein ID WP_176383214.1
Coordinates 4006982..4007398 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8765_RS18320 4002354..4003718 - 1365 WP_176384283.1 DUF4055 domain-containing protein -
G8765_RS18325 4003733..4005019 - 1287 WP_176383220.1 terminase family protein -
G8765_RS18330 4005000..4005548 - 549 WP_176383218.1 Hin recombinase -
G8765_RS18335 4005637..4006119 - 483 WP_176383216.1 hypothetical protein -
G8765_RS18340 4006744..4006920 + 177 WP_176386214.1 type II toxin-antitoxin system HicA family toxin Toxin
G8765_RS18345 4006982..4007398 + 417 WP_176383214.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G8765_RS18350 4007794..4008651 + 858 WP_176384285.1 hypothetical protein -
G8765_RS18355 4008694..4009233 - 540 WP_176386215.1 hypothetical protein -
G8765_RS18360 4009311..4009736 - 426 WP_176383210.1 hypothetical protein -
G8765_RS18365 4009736..4010080 - 345 WP_116746004.1 DUF1064 domain-containing protein -
G8765_RS18370 4010490..4011339 - 850 Protein_3591 ATP-binding protein -
G8765_RS18375 4011326..4012090 - 765 WP_176384287.1 YdaU family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3973417..4085849 112432


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6657.86 Da        Isoelectric Point: 10.9862

>T151629 WP_176386214.1 NZ_CP049828:4006744-4006920 [Janthinobacterium lividum]
VKQSEFVRWLKLQGATFKEGTNHLKVYLNGKQTILPRHPSKELKTGLVEGVKKQLNLK

Download         Length: 177 bp

>T151629 NZ_CP065624:c1555746-1555432 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14845.96 Da        Isoelectric Point: 4.5438

>AT151629 WP_176383214.1 NZ_CP049828:4006982-4007398 [Janthinobacterium lividum]
MKYPATFTPAPEGGYVVTFRDIPEAIAQGDDEAEALAEARSALATAMDFYFEDRRAAPTPSAALPGERLISLPASVSAKV
LLLNEMAAQNMRPAELARRLGVKPQEVTRLLDLAHTTKIDAIEDAMHALGRELEVVAA

Download         Length: 417 bp

>AT151629 NZ_CP065624:c1555435-1555019 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References