Detailed information of TA system TA151629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 4006744..4007398
• Replicon: chromosome
• Accession: NZ_CP049828
• Organism: Janthinobacterium lividum strain EIF2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: G8765_RS18340
• Protein ID: WP_176386214.1
• Coordinates: 4006744..4006920 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: G8765_RS18345
• Protein ID: WP_176383214.1
• Coordinates: 4006982..4007398 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G8765_RS18320	4002354..4003718	-	1365	WP_176384283.1	DUF4055 domain-containing protein	-
G8765_RS18325	4003733..4005019	-	1287	WP_176383220.1	terminase family protein	-
G8765_RS18330	4005000..4005548	-	549	WP_176383218.1	Hin recombinase	-
G8765_RS18335	4005637..4006119	-	483	WP_176383216.1	hypothetical protein	-
G8765_RS18340	4006744..4006920	+	177	WP_176386214.1	type II toxin-antitoxin system HicA family toxin	Toxin
G8765_RS18345	4006982..4007398	+	417	WP_176383214.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
G8765_RS18350	4007794..4008651	+	858	WP_176384285.1	hypothetical protein	-
G8765_RS18355	4008694..4009233	-	540	WP_176386215.1	hypothetical protein	-
G8765_RS18360	4009311..4009736	-	426	WP_176383210.1	hypothetical protein	-
G8765_RS18365	4009736..4010080	-	345	WP_116746004.1	DUF1064 domain-containing protein	-
G8765_RS18370	4010490..4011339	-	850	Protein_3591	ATP-binding protein	-
G8765_RS18375	4011326..4012090	-	765	WP_176384287.1	YdaU family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3973417..4085849	112432

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6657.86 Da
• Isoelectric Point: 10.9862

>T151629 WP_176386214.1 NZ_CP049828:4006744-4006920 [Janthinobacterium lividum]
VKQSEFVRWLKLQGATFKEGTNHLKVYLNGKQTILPRHPSKELKTGLVEGVKKQLNLK

Nucleotide

• Length: 177 bp

>T151629 NZ_CP065624:c1555746-1555432 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14845.96 Da
• Isoelectric Point: 4.5438

>AT151629 WP_176383214.1 NZ_CP049828:4006982-4007398 [Janthinobacterium lividum]
MKYPATFTPAPEGGYVVTFRDIPEAIAQGDDEAEALAEARSALATAMDFYFEDRRAAPTPSAALPGERLISLPASVSAKV
LLLNEMAAQNMRPAELARRLGVKPQEVTRLLDLAHTTKIDAIEDAMHALGRELEVVAA

Nucleotide

• Length: 417 bp

>AT151629 NZ_CP065624:c1555435-1555019 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA