Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3054603..3055256 Replicon chromosome
Accession NZ_CP049828
Organism Janthinobacterium lividum strain EIF2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G8765_RS14025 Protein ID WP_176386144.1
Coordinates 3055092..3055256 (-) Length 55 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G8765_RS14020 Protein ID WP_176383214.1
Coordinates 3054603..3055019 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8765_RS30340 3049919..3051517 + 1599 WP_213086112.1 ATP-binding protein -
G8765_RS14000 3051554..3051928 + 375 WP_176383208.1 hypothetical protein -
G8765_RS14005 3051928..3052272 + 345 WP_116746004.1 DUF1064 domain-containing protein -
G8765_RS14010 3052272..3052697 + 426 WP_176383210.1 hypothetical protein -
G8765_RS14015 3053352..3054173 - 822 WP_176383212.1 hypothetical protein -
G8765_RS14020 3054603..3055019 - 417 WP_176383214.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G8765_RS14025 3055092..3055256 - 165 WP_176386144.1 type II toxin-antitoxin system HicA family toxin Toxin
G8765_RS14030 3055879..3056361 + 483 WP_176383216.1 hypothetical protein -
G8765_RS14035 3056450..3056998 + 549 WP_176383218.1 Hin recombinase -
G8765_RS14040 3056979..3058265 + 1287 WP_176383220.1 terminase family protein -
G8765_RS14045 3058280..3059662 + 1383 WP_176383222.1 DUF4055 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3025305..3200568 175263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-49)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 55 a.a.        Molecular weight: 6161.16 Da        Isoelectric Point: 10.8255

>T151628 WP_176386144.1 NZ_CP049828:c3055256-3055092 [Janthinobacterium lividum]
VKQSEFVRWLKLQGATFKEGTNHLKVYLNGKQTILPRHPSKELKTGLVEGVKNN

Download         Length: 165 bp

>T151628 NZ_CP065624:c1335355-1334948 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTATGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14845.96 Da        Isoelectric Point: 4.5438

>AT151628 WP_176383214.1 NZ_CP049828:c3055019-3054603 [Janthinobacterium lividum]
MKYPATFTPAPEGGYVVTFRDIPEAIAQGDDEAEALAEARSALATAMDFYFEDRRAAPTPSAALPGERLISLPASVSAKV
LLLNEMAAQNMRPAELARRLGVKPQEVTRLLDLAHTTKIDAIEDAMHALGRELEVVAA

Download         Length: 417 bp

>AT151628 NZ_CP065624:c1335602-1335336 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References