Detailed information of TA system TA151627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/StbC(antitoxin)
• Location: 1287728..1288357
• Replicon: chromosome
• Accession: NZ_CP049828
• Organism: Janthinobacterium lividum strain EIF2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G8765_RS05780
• Protein ID: WP_176374738.1
• Coordinates: 1287941..1288357 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1G8GYN1
• Locus tag: G8765_RS05775
• Protein ID: WP_034784992.1
• Coordinates: 1287728..1287937 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G8765_RS05755	1283488..1284567	-	1080	WP_176374736.1	alpha/beta hydrolase	-
G8765_RS05760	1285072..1286310	+	1239	WP_034784989.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-
G8765_RS05765	1286307..1287188	+	882	WP_176374737.1	ATP-binding protein	-
G8765_RS05770	1287185..1287607	+	423	WP_070258873.1	NUDIX domain-containing protein	-
G8765_RS05775	1287728..1287937	+	210	WP_034784992.1	hypothetical protein	Antitoxin
G8765_RS05780	1287941..1288357	+	417	WP_176374738.1	VapC toxin family PIN domain ribonuclease	Toxin
G8765_RS05785	1288361..1288552	-	192	WP_034785391.1	DNA gyrase inhibitor YacG	-
G8765_RS05790	1288571..1289326	-	756	WP_034748811.1	cell division protein ZapD	-
G8765_RS05795	1289389..1290036	-	648	WP_176374739.1	dephospho-CoA kinase	-
G8765_RS05800	1290069..1290938	-	870	WP_151092752.1	A24 family peptidase	-
G8765_RS05805	1291041..1292237	-	1197	WP_176381908.1	type II secretion system F family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-109)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14874.17 Da
• Isoelectric Point: 5.6436

>T151627 WP_176374738.1 NZ_CP049828:1287941-1288357 [Janthinobacterium lividum]
MPAYLVDTDVIVAGRKGGAAPAGVLDFFERVAPEMRYVPVQVIAQLRAGIQRSWRREAALEALALEGWLEAVLAEYAPRL
LEFDLDCALVCARLHARGHAHGVDGQIAAMGIAYGLTVVSGRLDSFAAQGLRLENPFS

Nucleotide

• Length: 417 bp

>T151627 NZ_CP065624:1309208-1309543 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7936.07 Da
• Isoelectric Point: 6.8798

>AT151627 WP_034784992.1 NZ_CP049828:1287728-1287937 [Janthinobacterium lividum]
MPLTLTFTDTDELLIAALHKRARAHGRSIEDEHRDILRSALRPLPKRPLDDILRGMPDVGHDADFERRP

Nucleotide

• Length: 210 bp

>AT151627 NZ_CP065624:1308960-1309208 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1G8GYN1