Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2403073..2403590 Replicon chromosome
Accession NZ_CP049819
Organism Arthrobacter woluwensis strain QTS

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag G8758_RS10970 Protein ID WP_208186735.1
Coordinates 2403303..2403590 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag G8758_RS10965 Protein ID WP_208186733.1
Coordinates 2403073..2403306 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8758_RS10945 (G8758_10935) 2399641..2400750 + 1110 WP_208186727.1 LPXTG cell wall anchor domain-containing protein -
G8758_RS10950 (G8758_10940) 2400908..2401558 + 651 WP_208186728.1 HAD-IA family hydrolase -
G8758_RS10955 (G8758_10945) 2401613..2402170 + 558 WP_208186729.1 N-acetyltransferase -
G8758_RS10960 (G8758_10950) 2402156..2402947 - 792 WP_243874635.1 SDR family oxidoreductase -
G8758_RS10965 (G8758_10955) 2403073..2403306 + 234 WP_208186733.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
G8758_RS10970 (G8758_10960) 2403303..2403590 + 288 WP_208186735.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8758_RS10975 (G8758_10965) 2403639..2404637 - 999 WP_208186737.1 glycosyltransferase family 4 protein -
G8758_RS10980 (G8758_10970) 2404634..2405026 - 393 WP_208186738.1 6-carboxytetrahydropterin synthase -
G8758_RS10985 (G8758_10975) 2405030..2406037 - 1008 WP_208186740.1 zinc-binding alcohol dehydrogenase -
G8758_RS10990 (G8758_10980) 2406167..2407390 - 1224 WP_208186742.1 hypothetical protein -
G8758_RS10995 (G8758_10985) 2407463..2408335 + 873 WP_208186743.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10927.36 Da        Isoelectric Point: 8.0672

>T151626 WP_208186735.1 NZ_CP049819:2403303-2403590 [Arthrobacter woluwensis]
MSFRLTPAARADLSSIWDYTAERWDTRQAETYIRELHAAIERFAEDPAKGRTCDEIRAGYRKYAIGSHLIFYVVAADGVD
VIRVLHQRMGSSRHL

Download         Length: 288 bp

>T151626 NZ_CP065624:c1104487-1104176 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTCTCTACGCCAGAAGAGATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8249.13 Da        Isoelectric Point: 4.7906

>AT151626 WP_208186733.1 NZ_CP049819:2403073-2403306 [Arthrobacter woluwensis]
MSSNTSISLDEHSAAFLAREVKSGRFRTASEAVRAGLRLLEDQETHLAALRASLADGESSGTPEPFDLEAFLAEKKG

Download         Length: 234 bp

>AT151626 NZ_CP065624:c1104179-1103760 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACCAAGAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGCGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References