Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2119536..2119998 Replicon chromosome
Accession NZ_CP049802
Organism Staphylococcus warneri strain Cap 100.1

Toxin (Protein)


Gene name TsaT Uniprot ID A0A2V3ZEQ2
Locus tag G9P47_RS10400 Protein ID WP_002465948.1
Coordinates 2119813..2119998 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A364UQZ8
Locus tag G9P47_RS10395 Protein ID WP_015365250.1
Coordinates 2119536..2119793 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P47_RS10355 (G9P47_10365) 2114744..2115067 + 324 WP_015365247.1 thioredoxin family protein -
G9P47_RS10360 (G9P47_10370) 2115179..2115718 - 540 WP_002465937.1 nitroreductase -
G9P47_RS10365 (G9P47_10375) 2115796..2116512 - 717 WP_002465941.1 type I 3-dehydroquinate dehydratase -
G9P47_RS10370 (G9P47_10380) 2116688..2117110 + 423 WP_002450862.1 organic hydroperoxide resistance protein -
G9P47_RS10375 (G9P47_10385) 2117388..2117882 + 495 WP_002465942.1 GNAT family N-acetyltransferase -
G9P47_RS10380 (G9P47_10390) 2118015..2118605 - 591 WP_002465945.1 histidine phosphatase family protein -
G9P47_RS10385 (G9P47_10395) 2118814..2119047 + 234 WP_002450865.1 hypothetical protein -
G9P47_RS10390 (G9P47_10400) 2119039..2119242 - 204 WP_002465950.1 sterile alpha motif-like domain-containing protein -
G9P47_RS10395 (G9P47_10405) 2119536..2119793 + 258 WP_015365250.1 hypothetical protein Antitoxin
G9P47_RS10400 (G9P47_10410) 2119813..2119998 + 186 WP_002465948.1 hypothetical protein Toxin
G9P47_RS10405 (G9P47_10415) 2120204..2120680 + 477 WP_002465936.1 lipoprotein N-acylation protein LnsA -
G9P47_RS10410 (G9P47_10420) 2120740..2120973 - 234 WP_002450870.1 hypothetical protein -
G9P47_RS10415 (G9P47_10425) 2121238..2121990 + 753 WP_002465946.1 poly-gamma-glutamate hydrolase family protein -
G9P47_RS10420 (G9P47_10430) 2122081..2122365 + 285 WP_002465939.1 hypothetical protein -
G9P47_RS10425 (G9P47_10435) 2122443..2122658 + 216 WP_002465949.1 hypothetical protein -
G9P47_RS10430 (G9P47_10440) 2123123..2123362 + 240 WP_002465943.1 hypothetical protein -
G9P47_RS10435 (G9P47_10445) 2123591..2123824 + 234 WP_015365252.1 hypothetical protein -
G9P47_RS10440 (G9P47_10450) 2123999..2124199 - 201 WP_002450876.1 cold-shock protein -
G9P47_RS10445 (G9P47_10455) 2124520..2124885 - 366 WP_002466279.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6977.68 Da        Isoelectric Point: 10.1605

>T151621 WP_002465948.1 NZ_CP049802:2119813-2119998 [Staphylococcus warneri]
MSLHFTILFWLSLIFIVAGAIILAIMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLLFGL

Download         Length: 186 bp

>T151621 NZ_CP065623:c29150-28875 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCTAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9908.17 Da        Isoelectric Point: 4.5910

>AT151621 WP_015365250.1 NZ_CP049802:2119536-2119793 [Staphylococcus warneri]
MKLYIIHAINIILTILFIIFNVIITYNANLDDTLWLVPGLIVCGLIMMISFAIAITKKDLLSEVLFFINIILTLYYIYPI
FYDFL

Download         Length: 258 bp

>AT151621 NZ_CP065623:c29434-29150 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3ZEQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A364UQZ8

References