Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1158860..1159666 Replicon chromosome
Accession NZ_CP049802
Organism Staphylococcus warneri strain Cap 100.1

Toxin (Protein)


Gene name tsbT Uniprot ID A0A364UNB4
Locus tag G9P47_RS05800 Protein ID WP_002466824.1
Coordinates 1159487..1159666 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A364UN40
Locus tag G9P47_RS05795 Protein ID WP_015364870.1
Coordinates 1158860..1159459 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P47_RS05775 (G9P47_05795) 1154661..1156121 + 1461 WP_002466813.1 ABC transporter substrate-binding protein/permease -
G9P47_RS05780 (G9P47_05800) 1156114..1156836 + 723 WP_002466809.1 amino acid ABC transporter ATP-binding protein -
G9P47_RS05785 (G9P47_05805) 1157079..1158209 + 1131 WP_002466804.1 tRNA epoxyqueuosine(34) reductase QueG -
G9P47_RS05790 (G9P47_05810) 1158210..1158680 + 471 WP_002466802.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
G9P47_RS05795 (G9P47_05815) 1158860..1159459 + 600 WP_015364870.1 glucosamine-6-phosphate isomerase Antitoxin
G9P47_RS05800 (G9P47_05820) 1159487..1159666 + 180 WP_002466824.1 SAS053 family protein Toxin
G9P47_RS05805 (G9P47_05825) 1159809..1160201 + 393 WP_015364871.1 hypothetical protein -
G9P47_RS05810 (G9P47_05830) 1160356..1161741 + 1386 WP_002466811.1 class II fumarate hydratase -
G9P47_RS05815 (G9P47_05835) 1161802..1162632 - 831 WP_002466807.1 RluA family pseudouridine synthase -
G9P47_RS05820 (G9P47_05840) 1162810..1163922 + 1113 WP_002466816.1 GAF domain-containing sensor histidine kinase -
G9P47_RS05825 (G9P47_05845) 1163943..1164566 + 624 WP_002466822.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6901.22 Da        Isoelectric Point: 3.8441

>T151617 WP_002466824.1 NZ_CP049802:1159487-1159666 [Staphylococcus warneri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Download         Length: 180 bp

>T151617 NZ_CP065616:85355-85516 [Escherichia coli]
ATGAAACTACCGGGAAACGCCCTTATCTGGTGCGTATTAATCGTGTGCTGCACATTGTTGATATTCACACTCCTGACCCG
GAATCGCCTGTGCGAAGTCCGGCTGAAGGACGGATACAGGGAAGTTACGGCAACAATGGCTTACGAATCCGGCGGTAAGT
AG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22602.48 Da        Isoelectric Point: 4.8492

>AT151617 WP_015364870.1 NZ_CP049802:1158860-1159459 [Staphylococcus warneri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT151617 NZ_CP065616:c85309-85106 [Escherichia coli]
GTGGACTAGACATGCAGAGGCCTCGTGGGTTAATGAAAATTAACTACGGGGCTTTTGGCCTTCTGCCACACGACAGGATA
ACAAACCACCTTCACGTCATGAGGCAGAAAGCCTCAAGCGCCGGGCACATCATAGCCCATATACCTGCACGCTGACCACA
CTCGCTTTCCCTGAAAATAATCTGGTCGTTCAGCCAGTTCACGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A364UN40

References