Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1006025..1006554 Replicon chromosome
Accession NZ_CP049802
Organism Staphylococcus warneri strain Cap 100.1

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag G9P47_RS04870 Protein ID WP_002451625.1
Coordinates 1006192..1006554 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag G9P47_RS04865 Protein ID WP_002451626.1
Coordinates 1006025..1006195 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P47_RS04840 (G9P47_04865) 1001850..1002323 + 474 WP_002466763.1 PH domain-containing protein -
G9P47_RS04845 (G9P47_04870) 1002316..1003842 + 1527 WP_002466774.1 PH domain-containing protein -
G9P47_RS04850 (G9P47_04875) 1003829..1004332 + 504 WP_015364833.1 PH domain-containing protein -
G9P47_RS04855 (G9P47_04880) 1004359..1004733 + 375 WP_002466788.1 holo-ACP synthase -
G9P47_RS04860 (G9P47_04885) 1004785..1005933 + 1149 WP_015364834.1 alanine racemase -
G9P47_RS04865 (G9P47_04890) 1006025..1006195 + 171 WP_002451626.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
G9P47_RS04870 (G9P47_04895) 1006192..1006554 + 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G9P47_RS04875 (G9P47_04900) 1006877..1007878 + 1002 WP_002466762.1 PP2C family protein-serine/threonine phosphatase -
G9P47_RS04880 (G9P47_04905) 1007972..1008298 + 327 WP_002466754.1 anti-sigma factor antagonist -
G9P47_RS04885 (G9P47_04910) 1008300..1008779 + 480 WP_002466768.1 anti-sigma B factor RsbW -
G9P47_RS04890 (G9P47_04915) 1008754..1009524 + 771 WP_002451621.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T151616 WP_002451625.1 NZ_CP049802:1006192-1006554 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

>T151616 NZ_CP065616:c57215-56910 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT151616 WP_002451626.1 NZ_CP049802:1006025-1006195 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT151616 NZ_CP065616:c57435-57217 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References