Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 994902..995412 Replicon chromosome
Accession NZ_CP049802
Organism Staphylococcus warneri strain Cap 100.1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A364UNH7
Locus tag G9P47_RS04810 Protein ID WP_002466743.1
Coordinates 995206..995412 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag G9P47_RS04805 Protein ID WP_002466760.1
Coordinates 994902..995195 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P47_RS04780 (G9P47_04805) 990028..990819 + 792 WP_002466779.1 hydroxyethylthiazole kinase -
G9P47_RS04785 (G9P47_04810) 990820..991461 + 642 WP_015364827.1 thiamine phosphate synthase -
G9P47_RS04790 (G9P47_04815) 991550..992419 + 870 WP_002466746.1 membrane protein insertase YidC -
G9P47_RS04795 (G9P47_04820) 992457..993101 - 645 WP_002466781.1 HD domain-containing protein -
G9P47_RS04800 (G9P47_04825) 993229..994713 - 1485 WP_002466786.1 cardiolipin synthase -
G9P47_RS04805 (G9P47_04830) 994902..995195 + 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
G9P47_RS04810 (G9P47_04835) 995206..995412 + 207 WP_002466743.1 heavy metal-associated domain-containing protein Toxin
G9P47_RS04815 (G9P47_04840) 995551..995688 + 138 WP_002466770.1 Lmo0850 family protein -
G9P47_RS04820 (G9P47_04845) 995828..997018 - 1191 WP_002466775.1 FtsW/RodA/SpoVE family cell cycle protein -
G9P47_RS04825 (G9P47_04850) 997376..998446 + 1071 WP_002466764.1 D-alanine--D-alanine ligase -
G9P47_RS04830 (G9P47_04855) 998462..999823 + 1362 WP_002466757.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7670.62 Da        Isoelectric Point: 3.8601

>T151615 WP_002466743.1 NZ_CP049802:995206-995412 [Staphylococcus warneri]
VQQKIVYTAGIETQEQSEAIKNLLTEMIGVYQVDIDINSGNITIEFETPANLNSIEKEIYDAGYKVLY

Download         Length: 207 bp

>T151615 NZ_CP065616:c4018-3536 [Escherichia coli]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTGTTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT151615 WP_002466760.1 NZ_CP049802:994902-995195 [Staphylococcus warneri]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT151615 NZ_CP065616:c4299-4009 [Escherichia coli]
ATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGAGGAACGAGCCGT
TATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGGAAGCTAAAAACA
TTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAAGCTCCTGTGCAG
AATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNH7

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References