Detailed information of TA system TA151612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1861107..1861742
• Replicon: chromosome
• Accession: NZ_CP049801
• Organism: Acinetobacter shaoyimingii strain 323-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: G8E00_RS08300
• Protein ID: WP_166223638.1
• Coordinates: 1861560..1861742 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: G8E00_RS08295
• Protein ID: WP_166223634.1
• Coordinates: 1861107..1861511 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G8E00_RS08270	1856515..1856898	-	384	WP_166009927.1	DUF2946 domain-containing protein	-
G8E00_RS08275	1857197..1857637	+	441	WP_166223623.1	MarR family transcriptional regulator	-
G8E00_RS08280	1857634..1858845	+	1212	WP_166223626.1	MFS transporter	-
G8E00_RS08285	1858995..1859597	-	603	WP_166223628.1	nitroreductase family protein	-
G8E00_RS08290	1859890..1860381	-	492	WP_166223631.1	hypothetical protein	-
G8E00_RS08295	1861107..1861511	-	405	WP_166223634.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
G8E00_RS08300	1861560..1861742	-	183	WP_166223638.1	type II toxin-antitoxin system HicA family toxin	Toxin
G8E00_RS08305	1861990..1863384	-	1395	WP_166223641.1	class II fumarate hydratase	-
G8E00_RS08310	1863580..1864581	-	1002	WP_166223644.1	UDP-glucose 4-epimerase GalE	-
G8E00_RS08315	1864655..1865023	+	369	WP_166009913.1	sulfurtransferase complex subunit TusD	-
G8E00_RS08320	1865067..1865417	+	351	WP_166009911.1	hypothetical protein	-
G8E00_RS08325	1865424..1865708	+	285	WP_166009909.1	hypothetical protein	-
G8E00_RS08330	1865769..1866092	+	324	WP_166009907.1	TusE/DsrC/DsvC family sulfur relay protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6773.00 Da
• Isoelectric Point: 10.4906

>T151612 WP_166223638.1 NZ_CP049801:c1861742-1861560 [Acinetobacter shaoyimingii]
MKSLDLIKMIEADGWYQVRCKGDHHHFKHPTKKGLVTIPHPKKDLPSGTVNSILKQAGLK

Nucleotide

• Length: 183 bp

>T151612 NZ_CP065615:c4133890-4133783 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14812.74 Da
• Isoelectric Point: 4.3813

>AT151612 WP_166223634.1 NZ_CP049801:c1861511-1861107 [Acinetobacter shaoyimingii]
MLYPIAVERGSDKEAFGVIVPDIQGCFSAGDTLEEALENAKEAIAGHLEILAEEGEEIPLPSEASNFFDDEDYKGMVWAV
VDVDVSRYLGKAEKVNVTLPSRLIHLIDDRVKKDTRYKSRSAFLAASAERMLHA

Nucleotide

• Length: 405 bp

>AT151612 NZ_CP065615:4133939-4134004 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT