Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 299653..300265 Replicon chromosome
Accession NZ_CP049799
Organism Streptococcus pyogenes strain 1040

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag G7052_RS01455 Protein ID WP_011018227.1
Coordinates 299930..300265 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag G7052_RS01450 Protein ID WP_002988079.1
Coordinates 299653..299940 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7052_RS01420 294830..295813 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
G7052_RS01425 295817..296746 - 930 WP_010922663.1 tagatose-6-phosphate kinase -
G7052_RS01430 296794..297309 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
G7052_RS01435 297344..297772 - 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
G7052_RS01440 298219..298992 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
G7052_RS01450 299653..299940 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
G7052_RS01455 299930..300265 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7052_RS08905 300417..300887 + 471 Protein_266 integrase -
G7052_RS01465 300933..301370 + 438 WP_111713473.1 site-specific integrase -
G7052_RS01470 301490..301882 - 393 WP_002982716.1 30S ribosomal protein S9 -
G7052_RS01475 301903..302349 - 447 WP_002982710.1 50S ribosomal protein L13 -
G7052_RS01480 302567..302773 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
G7052_RS01485 302770..303276 - 507 WP_002988070.1 hypothetical protein -
G7052_RS01490 303412..304272 - 861 WP_002982687.1 DegV family protein -
G7052_RS01495 304369..304887 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T151611 WP_011018227.1 NZ_CP049799:299930-300265 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T151611 NZ_CP065615:c4133407-4133300 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT151611 WP_002988079.1 NZ_CP049799:299653-299940 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT151611 NZ_CP065615:4133465-4133521 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References