Detailed information of TA system TA151608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 3073660..3075319
• Replicon: chromosome
• Accession: NZ_CP049795
• Organism: Delftia sp. WY8

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: G4D77_RS14195
• Protein ID: WP_227740854.1
• Coordinates: 3074489..3075319 (-)
• Length: 277 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: G4D77_RS14190
• Protein ID: WP_154836063.1
• Coordinates: 3073660..3074466 (-)
• Length: 269 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G4D77_RS14160	3069414..3070184	-	771	WP_012202888.1	SDR family oxidoreductase	-
G4D77_RS14165	3070739..3071014	+	276	WP_074931722.1	hypothetical protein	-
G4D77_RS14170	3071278..3071625	+	348	WP_017406311.1	type II toxin-antitoxin system RelE/ParE family toxin	-
G4D77_RS14175	3071622..3071930	+	309	WP_016452050.1	XRE family transcriptional regulator	-
G4D77_RS14180	3071943..3072704	-	762	WP_154836059.1	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	-
G4D77_RS14185	3072808..3073605	-	798	WP_154836061.1	aspartate dehydrogenase	-
G4D77_RS14190	3073660..3074466	-	807	WP_154836063.1	IclR family transcriptional regulator	Antitoxin
G4D77_RS14195	3074489..3075319	-	831	WP_227740854.1	alpha/beta fold hydrolase	Toxin
G4D77_RS14200	3075513..3076043	-	531	WP_016449821.1	cupin domain-containing protein	-
G4D77_RS14205	3076243..3077439	-	1197	WP_154836067.1	MFS transporter	-
G4D77_RS14210	3077462..3078346	-	885	WP_016449823.1	NAD(P)-dependent oxidoreductase	-
G4D77_RS14215	3078483..3079073	-	591	WP_013804518.1	TetR/AcrR family transcriptional regulator	-
G4D77_RS14220	3079155..3079646	-	492	WP_016449824.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (35-262)

Antitoxin

• Transcription regulator IclR, C-terminal (137-255)

Sequences

Toxin

Protein

• Length: 277 a.a.
• Molecular weight: 28673.91 Da
• Isoelectric Point: 7.8449

>T151608 WP_227740854.1 NZ_CP049795:c3075319-3074489 [Delftia sp. WY8]
MEQRLQAQFPEHLIALPGGAQVAWREAGDTASDFAVVMLHGISSGAASWMDVALALAPRTRVLAWGAPGYGRSTPLTPAA
PTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQGRLAALQE
KGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGRLAMPVEVWVGEHDVVTPPAACAA
WAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Nucleotide

• Length: 831 bp

>T151608 NZ_CP065615:c3220983-3220810 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 269 a.a.
• Molecular weight: 29075.13 Da
• Isoelectric Point: 5.3408

>AT151608 WP_154836063.1 NZ_CP049795:c3074466-3073660 [Delftia sp. WY8]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLEGMGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQSLCDRLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDV
DQLRALFGGSELPQFSESTPRSVEQLLQLLQQDHERGYAMGEGFYEPGVSSIAAPVRDAQGRIVAGLGMAVAFTEIAPGR
MADWVEQVRAAADELAGHLRTQHPGFLR

Nucleotide

• Length: 807 bp

>AT151608 NZ_CP065615:c3221307-3221011 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAGGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG