Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 2901909..2902570 Replicon chromosome
Accession NZ_CP049787
Organism Ralstonia solanacearum strain B2

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E7Z845
Locus tag G7968_RS13290 Protein ID WP_016727753.1
Coordinates 2902157..2902570 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7Z6P3
Locus tag G7968_RS13285 Protein ID WP_019717749.1
Coordinates 2901909..2902160 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7968_RS13260 2898364..2899311 + 948 WP_081365362.1 COG2958 family protein -
G7968_RS13265 2899336..2900160 - 825 WP_118872093.1 IS5 family transposase -
G7968_RS26120 2900319..2900657 - 339 WP_016727784.1 glycine zipper 2TM domain-containing protein -
G7968_RS13275 2900931..2901146 + 216 WP_071615547.1 hypothetical protein -
G7968_RS13280 2901300..2901532 - 233 Protein_2583 hypothetical protein -
G7968_RS13285 2901909..2902160 + 252 WP_019717749.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G7968_RS13290 2902157..2902570 + 414 WP_016727753.1 type II toxin-antitoxin system VapC family toxin Toxin
G7968_RS13295 2902642..2903664 - 1023 WP_020425162.1 DNA cytosine methyltransferase -
G7968_RS13300 2904288..2904575 + 288 WP_089190399.1 H-NS histone family protein -
G7968_RS13305 2904618..2905262 - 645 WP_165591538.1 hypothetical protein -
G7968_RS13310 2905237..2905458 - 222 WP_089190401.1 hypothetical protein -
G7968_RS13315 2905455..2905844 - 390 WP_165591539.1 hypothetical protein -
G7968_RS13320 2905999..2907018 - 1020 WP_028854752.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2899336..2900160 824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15586.89 Da        Isoelectric Point: 6.2337

>T151595 WP_016727753.1 NZ_CP049787:2902157-2902570 [Ralstonia solanacearum]
MSYLIDTNVLSELRRKAPDARVVAWMQDRPRQSLYLSVLTLGEIRKGIERLDDAARRQHLIDWLEVELPNYFLGRLLDID
AHTADRWGRLMSSAGRPLPAIDGLLAATALQHDLTLVTRNTKDFAGLDVQLINPWEA

Download         Length: 414 bp

>T151595 NZ_CP065613:c4858726-4858619 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9305.49 Da        Isoelectric Point: 5.0774

>AT151595 WP_019717749.1 NZ_CP049787:2901909-2902160 [Ralstonia solanacearum]
MQSWQMQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGGGESLVSFMRQSPLADQDDVVFERERSLPRE
VEF

Download         Length: 252 bp

>AT151595 NZ_CP065613:4858773-4858839 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References