Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 2759522..2760183 Replicon chromosome
Accession NZ_CP049787
Organism Ralstonia solanacearum strain B2

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E7Z845
Locus tag G7968_RS12575 Protein ID WP_016727753.1
Coordinates 2759770..2760183 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7Z6P3
Locus tag G7968_RS12570 Protein ID WP_019717749.1
Coordinates 2759522..2759773 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7968_RS12545 2755175..2755891 + 717 WP_049800424.1 Crp/Fnr family transcriptional regulator -
G7968_RS26110 2756562..2756900 - 339 WP_197716101.1 glycine zipper 2TM domain-containing protein -
G7968_RS12555 2757174..2757389 + 216 WP_071615547.1 hypothetical protein -
G7968_RS12560 2757543..2757775 - 233 Protein_2441 hypothetical protein -
G7968_RS12565 2758372..2759247 + 876 WP_049800423.1 hypothetical protein -
G7968_RS12570 2759522..2759773 + 252 WP_019717749.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G7968_RS12575 2759770..2760183 + 414 WP_016727753.1 type II toxin-antitoxin system VapC family toxin Toxin
G7968_RS12580 2760255..2761277 - 1023 WP_020425162.1 DNA cytosine methyltransferase -
G7968_RS12585 2761901..2762188 + 288 WP_089190399.1 H-NS histone family protein -
G7968_RS12590 2762231..2762875 - 645 WP_089190400.1 hypothetical protein -
G7968_RS12595 2762850..2763071 - 222 WP_089190401.1 hypothetical protein -
G7968_RS12600 2763068..2763457 - 390 WP_089190402.1 hypothetical protein -
G7968_RS12605 2763618..2764865 + 1248 WP_165591100.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15586.89 Da        Isoelectric Point: 6.2337

>T151594 WP_016727753.1 NZ_CP049787:2759770-2760183 [Ralstonia solanacearum]
MSYLIDTNVLSELRRKAPDARVVAWMQDRPRQSLYLSVLTLGEIRKGIERLDDAARRQHLIDWLEVELPNYFLGRLLDID
AHTADRWGRLMSSAGRPLPAIDGLLAATALQHDLTLVTRNTKDFAGLDVQLINPWEA

Download         Length: 414 bp

>T151594 NZ_CP065613:c4858190-4858083 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9305.49 Da        Isoelectric Point: 5.0774

>AT151594 WP_019717749.1 NZ_CP049787:2759522-2759773 [Ralstonia solanacearum]
MQSWQMQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGGGESLVSFMRQSPLADQDDVVFERERSLPRE
VEF

Download         Length: 252 bp

>AT151594 NZ_CP065613:4858243-4858304 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References