Detailed information of TA system TA151593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2127860..2129455
• Replicon: chromosome
• Accession: NZ_CP049787
• Organism: Ralstonia solanacearum strain B2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: G7968_RS09640
• Protein ID: WP_165591407.1
• Coordinates: 2128118..2129455 (+)
• Length: 446 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: G7968_RS09635
• Protein ID: WP_165591406.1
• Coordinates: 2127860..2128114 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7968_RS09605	2123923..2124849	-	927	WP_011001401.1	muramoyltetrapeptide carboxypeptidase	-
G7968_RS09610	2124846..2125397	-	552	WP_165591405.1	tRNA adenosine(34) deaminase TadA	-
G7968_RS09615	2125417..2125893	-	477	WP_011001399.1	6-carboxytetrahydropterin synthase QueD	-
G7968_RS09620	2125961..2126599	-	639	WP_020831956.1	7-carboxy-7-deazaguanine synthase	-
G7968_RS09630	2126917..2127756	+	840	WP_016725278.1	oxaloacetate decarboxylase	-
G7968_RS09635	2127860..2128114	+	255	WP_165591406.1	type II toxin-antitoxin system Y4mF family antitoxin	Antitoxin
G7968_RS09640	2128118..2129455	+	1338	WP_165591407.1	type II toxin-antitoxin system HipA family toxin	Toxin
G7968_RS09645	2129452..2130654	+	1203	WP_119417555.1	MFS transporter	-
G7968_RS09650	2130880..2131608	+	729	WP_087451929.1	DsbA family protein	-
G7968_RS09655	2131631..2132194	-	564	WP_082240038.1	RNA 2',3'-cyclic phosphodiesterase	-
G7968_RS09660	2132375..2133073	-	699	WP_058908491.1	protocatechuate 3,4-dioxygenase subunit alpha	-
G7968_RS09665	2133070..2133810	-	741	WP_011001390.1	protocatechuate 3,4-dioxygenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-107)

Antitoxin

• Transcription regulator, HipB-like (10-66)

Sequences

Toxin

Protein

• Length: 446 a.a.
• Molecular weight: 48778.81 Da
• Isoelectric Point: 6.7765

>T151593 WP_165591407.1 NZ_CP049787:2128118-2129455 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPHDFSGRVWSSVRTGVLAQAERFLNELASVTP

Nucleotide

• Length: 1338 bp

>T151593 NZ_CP065613:c4017766-4017548 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8750.08 Da
• Isoelectric Point: 10.4693

>AT151593 WP_165591406.1 NZ_CP049787:2127860-2128114 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGPPSAA
PADW

Nucleotide

• Length: 255 bp

>AT151593 NZ_CP065613:c4018166-4017792 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAATCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG