Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 262929..263590 Replicon chromosome
Accession NZ_CP049787
Organism Ralstonia solanacearum strain B2

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E7Z845
Locus tag G7968_RS01235 Protein ID WP_016727753.1
Coordinates 262929..263342 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7Z6P3
Locus tag G7968_RS01240 Protein ID WP_019717749.1
Coordinates 263339..263590 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7968_RS01205 259064..259216 + 153 WP_157698851.1 hypothetical protein -
G7968_RS01210 259292..259936 + 645 WP_086706230.1 hypothetical protein -
G7968_RS01220 260170..261015 - 846 WP_157698852.1 hypothetical protein -
G7968_RS01225 261402..261695 - 294 WP_020371973.1 hypothetical protein -
G7968_RS01230 261835..262857 + 1023 WP_086706232.1 DNA cytosine methyltransferase -
G7968_RS01235 262929..263342 - 414 WP_016727753.1 type II toxin-antitoxin system VapC family toxin Toxin
G7968_RS01240 263339..263590 - 252 WP_019717749.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G7968_RS01250 263967..264199 + 233 Protein_246 hypothetical protein -
G7968_RS01255 264353..264568 - 216 WP_071615547.1 hypothetical protein -
G7968_RS26055 264842..265180 + 339 WP_016727784.1 glycine zipper 2TM domain-containing protein -
G7968_RS01265 265855..266574 - 720 WP_205963244.1 helix-turn-helix domain-containing protein -
G7968_RS01270 267272..267886 + 615 WP_157698853.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 205925..270314 64389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15586.89 Da        Isoelectric Point: 6.2337

>T151591 WP_016727753.1 NZ_CP049787:c263342-262929 [Ralstonia solanacearum]
MSYLIDTNVLSELRRKAPDARVVAWMQDRPRQSLYLSVLTLGEIRKGIERLDDAARRQHLIDWLEVELPNYFLGRLLDID
AHTADRWGRLMSSAGRPLPAIDGLLAATALQHDLTLVTRNTKDFAGLDVQLINPWEA

Download         Length: 414 bp

>T151591 NZ_CP065613:c3748707-3748429 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGTATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9305.49 Da        Isoelectric Point: 5.0774

>AT151591 WP_019717749.1 NZ_CP049787:c263590-263339 [Ralstonia solanacearum]
MQSWQMQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGGGESLVSFMRQSPLADQDDVVFERERSLPRE
VEF

Download         Length: 252 bp

>AT151591 NZ_CP065613:c3748970-3748710 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGTGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References