151590

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 4853853..4854375 Replicon chromosome
Accession NZ_CP049786
Organism Leclercia sp. 29361

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag G7090_RS23230 Protein ID WP_166184929.1
Coordinates 4854088..4854375 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag G7090_RS23225 Protein ID WP_106995743.1
Coordinates 4853853..4854095 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7090_RS23200 4850445..4851347 + 903 WP_106995747.1 formate dehydrogenase subunit beta -
G7090_RS23205 4851344..4851979 + 636 WP_106995746.1 formate dehydrogenase cytochrome b556 subunit -
G7090_RS23210 4851976..4852905 + 930 WP_166184923.1 formate dehydrogenase accessory protein FdhE -
G7090_RS23215 4852944..4853234 - 291 WP_166184926.1 helix-turn-helix domain-containing protein -
G7090_RS23220 4853235..4853546 - 312 WP_106995744.1 toxin HigB-2 -
G7090_RS23225 4853853..4854095 + 243 WP_106995743.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
G7090_RS23230 4854088..4854375 + 288 WP_166184929.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7090_RS23235 4854381..4855322 - 942 WP_166184932.1 fatty acid biosynthesis protein FabY -
G7090_RS23240 4855367..4855804 - 438 WP_106995740.1 D-tyrosyl-tRNA(Tyr) deacylase -
G7090_RS23245 4855801..4856682 - 882 WP_106995739.1 virulence factor BrkB family protein -
G7090_RS23250 4856676..4857275 - 600 WP_106995738.1 glucose-1-phosphatase -
G7090_RS23255 4857394..4858194 - 801 WP_166184935.1 DeoR/GlpR family DNA-binding transcription regulator -
G7090_RS23260 4858229..4859125 - 897 WP_166184938.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11366.94 Da        Isoelectric Point: 7.4184

>T151590 WP_166184929.1 NZ_CP049786:4854088-4854375 [Leclercia sp. 29361]
MYRLSNLAAEDFEAIYEYTWRRFGPLQADKYTNELDGLLKLLARNPLMGRDCQNLIDGARRHDYGQHAIFYRHADDAIFV
IRILHQQMDPLRHFR

Download         Length: 288 bp

>T151590 NZ_CP065613:c3569922-3569644 [Escherichia coli]
ATGATAAAAAGCTGGAAACACAAAGGACTTCAACGTTTCTTTGAAACTGGAAGTGCATCAGGCGTAAATCCCAATCATGT
TAAACGCCTTAGAATGCGCCTTCAGGTGATAGATCAAGCCGAAATCATTGATGATATTAACCTTGCCGGTTACAGGCTGC
ACCAGTTGCAAGGAGACAGGGCCGATACGTGGTCTGTCTCCGTCTCCGGTAACTGGAGGATCACCTTCGAGTTTCGTGAC
GGTGACGCTTATATTCTTAACTACGAGGATTACCATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9014.25 Da        Isoelectric Point: 7.0156

>AT151590 WP_106995743.1 NZ_CP049786:4853853-4854095 [Leclercia sp. 29361]
MPRTTSITLGENLDQFINRMIESGRYGSTSEVVRSALRLLEEHELRTGKLREALEEGLLSGESSLTLQEIAARKKRNLNV

Download         Length: 243 bp

>AT151590 NZ_CP065613:c3569644-3569339 [Escherichia coli]
ATGACGATGTTTAACCCCCCTCATCCAGGAGAAATTATTGCGGATATTCTGGAAGATCAGAATATTGGGATCAGAGAGCT
GGCAAGAGCGCTTGATGTTGCGCCTTCCACTGTTCAGCGACTGGTTTCAGGAAATGCGGCAATCTCTCCTGAAATGGCTG
TTCGTCTCGCCGCCGTTCTTGGAGGAACTCCGGCCTCATGGATTCGTCTTCAGATGGCATGGAGTCTTGAAAAAGCAGAG
AGAGAAGTTGACATCTCTCATCTCTCAACAAAATACCGACCTGAAGAAATTCAGCCTCATCCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References