Detailed information of TA system TA151588

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4007183..4007843
• Replicon: chromosome
• Accession: NZ_CP049786
• Organism: Leclercia sp. 29361

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: G7090_RS19120
• Protein ID: WP_106994382.1
• Coordinates: 4007183..4007596 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A6G7TIV6
• Locus tag: G7090_RS19125
• Protein ID: WP_032613860.1
• Coordinates: 4007577..4007843 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7090_RS19100	4003184..4004917	-	1734	WP_166183877.1	single-stranded-DNA-specific exonuclease RecJ	-
G7090_RS19105	4004923..4005636	-	714	WP_106994385.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
G7090_RS19110	4005658..4006554	-	897	WP_106994384.1	site-specific tyrosine recombinase XerD	-
G7090_RS19115	4006657..4007178	+	522	WP_106994383.1	flavodoxin FldB	-
G7090_RS19120	4007183..4007596	-	414	WP_106994382.1	protein YgfX	Toxin
G7090_RS19125	4007577..4007843	-	267	WP_032613860.1	FAD assembly factor SdhE	Antitoxin
G7090_RS19130	4008148..4009128	+	981	WP_166183879.1	tRNA-modifying protein YgfZ	-
G7090_RS19135	4009214..4009873	-	660	WP_166183881.1	hemolysin III family protein	-
G7090_RS19140	4010038..4010349	-	312	WP_166183884.1	N(4)-acetylcytidine aminohydrolase	-
G7090_RS19145	4010402..4011133	+	732	WP_106994378.1	MurR/RpiR family transcriptional regulator	-
G7090_RS19150	4011247..4012680	+	1434	WP_166183886.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16200.98 Da
• Isoelectric Point: 10.9865

>T151588 WP_106994382.1 NZ_CP049786:c4007596-4007183 [Leclercia sp. 29361]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLMPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLHWQGS
EWEIVGTPWMLNSGMMLRLRKGSGKRYQHLWLAADSMDEGEWRDLRRMLSQQPTHGR

Nucleotide

• Length: 414 bp

>T151588 NZ_CP065613:3137113-3137286 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTTTCTCTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10539.06 Da
• Isoelectric Point: 4.6787

>AT151588 WP_032613860.1 NZ_CP049786:c4007843-4007577 [Leclercia sp. 29361]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT151588 NZ_CP065613:3136789-3137085 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAGGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A6G7TIV6