Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3053846..3054436 Replicon chromosome
Accession NZ_CP049786
Organism Leclercia sp. 29361

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag G7090_RS14720 Protein ID WP_166182901.1
Coordinates 3053846..3054178 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag G7090_RS14725 Protein ID WP_166182902.1
Coordinates 3054179..3054436 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7090_RS14690 3048922..3049998 + 1077 WP_166182899.1 porin -
G7090_RS14695 3050132..3051745 + 1614 WP_166182900.1 sensor histidine kinase -
G7090_RS14700 3051742..3052467 + 726 WP_106993444.1 two-component system response regulator DcuR -
G7090_RS14710 3052814..3053611 + 798 WP_106993445.1 DgsA anti-repressor MtfA -
G7090_RS14720 3053846..3054178 - 333 WP_166182901.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G7090_RS14725 3054179..3054436 - 258 WP_166182902.1 antitoxin Antitoxin
G7090_RS14730 3054542..3054844 - 303 WP_106993446.1 helix-turn-helix transcriptional regulator -
G7090_RS14735 3054848..3055201 - 354 WP_166182903.1 type II toxin-antitoxin system RelE/ParE family toxin -
G7090_RS14740 3055396..3056346 - 951 WP_166182904.1 HTH-type transcriptional regulator Cbl -
G7090_RS14745 3056443..3057360 - 918 WP_106993448.1 nitrogen assimilation transcriptional regulator NAC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-107)

Antitoxin

Antitoxin PemI-like

(4-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11829.73 Da        Isoelectric Point: 9.3476

>T151585 WP_166182901.1 NZ_CP049786:c3054178-3053846 [Leclercia sp. 29361]
MERGEIWLVSLDPTTGHEQSGKRPVLIVSPAAFNHLTRVPVAVPITTGGKFARTAGFAVSLDEVGLKTTGVIRCDQPRTI
DMGARHGVKLERVPDSVMNEVLARLGTLLT

Download         Length: 333 bp

>T151585 NZ_CP065613:c2452002-2451895 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9214.68 Da        Isoelectric Point: 4.7512

>AT151585 WP_166182902.1 NZ_CP049786:c3054436-3054179 [Leclercia sp. 29361]
MYTTRLKKVGGSVMLAVPPAVLKTLGLQPDSEVGVTINKGCLIVEPQKRPHYSLAELLAQCDPQAELSEEDREWIDGPAA
GKEIL

Download         Length: 258 bp

>AT151585 NZ_CP065613:2452051-2452116 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References