Detailed information of TA system TA151575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2334134..2335707
• Replicon: chromosome
• Accession: NZ_CP049786
• Organism: Leclercia sp. 29361

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: G7090_RS11160
• Protein ID: WP_166185237.1
• Coordinates: 2334134..2335426 (-)
• Length: 431 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: G7090_RS11165
• Protein ID: WP_166182439.1
• Coordinates: 2335456..2335707 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7090_RS11135	2330660..2331289	-	630	Protein_2175	YncE family protein	-
G7090_RS11140	2331566..2332570	-	1005	WP_000427623.1	IS110-like element IS4321 family transposase	-
G7090_RS11145	2332745..2333170	-	426	WP_103793560.1	glutaredoxin-dependent arsenate reductase	-
G7090_RS11150	2333183..2333587	-	405	Protein_2178	arsenical efflux pump membrane protein ArsB	-
G7090_RS11155	2333580..2334017	-	438	Protein_2179	YncE family protein	-
G7090_RS11160	2334134..2335426	-	1293	WP_166185237.1	type II toxin-antitoxin system HipA family toxin	Toxin
G7090_RS11165	2335456..2335707	-	252	WP_166182439.1	helix-turn-helix domain-containing protein	Antitoxin
G7090_RS11170	2336513..2340313	+	3801	WP_166182440.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2331566..2332570	1004

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (142-390)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 431 a.a.
• Molecular weight: 47658.82 Da
• Isoelectric Point: 7.8181

>T151575 WP_166185237.1 NZ_CP049786:c2335426-2334134 [Leclercia sp. 29361]
MNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRGISLSLPLQHSRIKGAQVFNFFSNLLPDSEAIIARMQARFQVETAHPF
DLLASVGRDCVGAIQLYPPGQEIPPVKNMVAEPLDDKQIAALLDGYQMAPLGMTEEGADFRISLAGAQEKTALLWYQDRW
QRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAHAEMARFGGKKVLIIERFDRRWARSGWLMRL
PQEDFCQAQGVSPALKYESHGGPGIADAMKLLLGSRLAGQDREMFFKTQILFWMLAAIDGHGKNFSLFIEADSSFRMTPL
YDVISAFPLFKAGGIPIKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGFSQEAARRLMTEMAERTDEVIASVRAELP
SDFPPQVSKAIFDGLASQAARIGRFNGLAT

Nucleotide

• Length: 1293 bp

>T151575 NZ_CP065613:c424003-423907 [Escherichia coli]
CACCTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACAGGAATC
GTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9180.49 Da
• Isoelectric Point: 9.8953

>AT151575 WP_166182439.1 NZ_CP049786:c2335707-2335456 [Leclercia sp. 29361]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSDFENKPGSTKLETLFKILAALDLELHLVKRGASLPDNNAWT
KEW

Nucleotide

• Length: 252 bp

>AT151575 NZ_CP065613:423869-424000 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAG