Detailed information of TA system TA151573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1153477..1154096
• Replicon: chromosome
• Accession: NZ_CP049786
• Organism: Leclercia sp. 29361

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A345CDT0
• Locus tag: G7090_RS05410
• Protein ID: WP_032616864.1
• Coordinates: 1153477..1153695 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: G7090_RS05415
• Protein ID: WP_106992181.1
• Coordinates: 1153704..1154096 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7090_RS05390	1150485..1150838	+	354	WP_106992177.1	DUF1428 family protein	-
G7090_RS05395	1150871..1152439	-	1569	WP_166181745.1	EAL domain-containing protein	-
G7090_RS05400	1152632..1152772	+	141	WP_106992179.1	type B 50S ribosomal protein L36	-
G7090_RS05405	1152832..1153296	-	465	WP_166181746.1	hypothetical protein	-
G7090_RS05410	1153477..1153695	-	219	WP_032616864.1	hemolysin expression modulator Hha	Toxin
G7090_RS05415	1153704..1154096	-	393	WP_106992181.1	Hha toxicity modulator TomB	Antitoxin
G7090_RS05420	1154587..1157727	-	3141	WP_166181747.1	multidrug efflux RND transporter permease subunit AcrB	-
G7090_RS05425	1157750..1158943	-	1194	WP_106992183.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-115)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8583.95 Da
• Isoelectric Point: 8.9008

>T151573 WP_032616864.1 NZ_CP049786:c1153695-1153477 [Leclercia sp. 29361]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Nucleotide

• Length: 219 bp

>T151573 NZ_CP065612:c233072-232590 [Escherichia coli]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTGTTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATAAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15093.00 Da
• Isoelectric Point: 4.8941

>AT151573 WP_106992181.1 NZ_CP049786:c1154096-1153704 [Leclercia sp. 29361]
MDEYSPKRQDIAQLKFLCESLYHDCLTNLDESNHGWVNDPTSAINLQLNELIEHIAAFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVTASRANPLASPVKIITNN

Nucleotide

• Length: 393 bp

>AT151573 NZ_CP065612:c233365-233063 [Escherichia coli]
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Structures

Toxin

• AlphaFold DB: A0A345CDT0