Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 589025..589569 Replicon chromosome
Accession NZ_CP049786
Organism Leclercia sp. 29361

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag G7090_RS02810 Protein ID WP_106996107.1
Coordinates 589258..589569 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag G7090_RS02805 Protein ID WP_166181457.1
Coordinates 589025..589258 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7090_RS02780 584430..586097 + 1668 WP_166181452.1 hypothetical protein -
G7090_RS02785 586205..586540 - 336 WP_166181453.1 endoribonuclease SymE -
G7090_RS02790 586743..587120 - 378 WP_166181454.1 acyl carrier protein -
G7090_RS02795 587249..587776 + 528 WP_166181455.1 hypothetical protein -
G7090_RS02800 587842..588894 + 1053 WP_166181456.1 DUF1176 domain-containing protein -
G7090_RS02805 589025..589258 + 234 WP_166181457.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
G7090_RS02810 589258..589569 + 312 WP_106996107.1 CcdB family protein Toxin
G7090_RS02815 589669..590352 - 684 WP_166181458.1 DNA-binding transcriptional regulator CsiR -
G7090_RS02820 590398..591681 - 1284 WP_166181459.1 4-aminobutyrate--2-oxoglutarate transaminase -
G7090_RS02825 591696..593144 - 1449 WP_166181460.1 NADP-dependent succinate-semialdehyde dehydrogenase -
G7090_RS02830 593168..593419 - 252 Protein_550 L-2-hydroxyglutarate oxidase -
G7090_RS02835 593502..593786 + 285 WP_106996114.1 hypothetical protein -
G7090_RS02840 593798..594193 + 396 WP_207630094.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-102)

Antitoxin

Post-segregation antitoxin CcdA

(7-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11695.62 Da        Isoelectric Point: 7.9729

>T151570 WP_106996107.1 NZ_CP049786:589258-589569 [Leclercia sp. 29361]
MQFCVYRNKGKNKAYPYLLEVQSPLADDYLGAKLVIPLAKSDFFSSKIPERMFPLVVINGQQYRLITADIVAAPNELFGD
KVADLRHQSDLIKGAIDFMFYGF

Download         Length: 312 bp

>T151570 NZ_CP065612:c30724-30419 [Escherichia coli]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8919.11 Da        Isoelectric Point: 5.8719

>AT151570 WP_166181457.1 NZ_CP049786:589025-589258 [Leclercia sp. 29361]
MIRTEPKRAVTLTVDPALYDEVKQSGANISALLNKALLDEQKRLQAARWTEENREGLEEMRRFFETHGRFSDELGKL

Download         Length: 234 bp

>AT151570 NZ_CP065612:c30944-30726 [Escherichia coli]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References