Detailed information of TA system TA151542

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 573429..573970
• Replicon: chromosome
• Accession: NZ_CP049774
• Organism: Mesoflavibacter sp. HG37

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A137REF7
• Locus tag: C7H56_RS02720
• Protein ID: WP_062623211.1
• Coordinates: 573668..573970 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A5M7B575
• Locus tag: C7H56_RS02715
• Protein ID: WP_028284019.1
• Coordinates: 573429..573671 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7H56_RS02680	568476..569033	+	558	WP_106687026.1	hypothetical protein	-
C7H56_RS02685	569298..570011	+	714	WP_191073026.1	hypothetical protein	-
C7H56_RS02690	570225..570515	+	291	WP_106687046.1	hypothetical protein	-
C7H56_RS02695	570525..570740	+	216	WP_106687025.1	hypothetical protein	-
C7H56_RS02700	570893..571762	+	870	WP_106687024.1	hypothetical protein	-
C7H56_RS02705	571913..572449	+	537	WP_106687023.1	YcxB family protein	-
C7H56_RS02710	572605..573240	+	636	WP_106687022.1	hypothetical protein	-
C7H56_RS02715	573429..573671	+	243	WP_028284019.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
C7H56_RS02720	573668..573970	+	303	WP_062623211.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C7H56_RS02725	574135..574635	+	501	WP_106687020.1	hypothetical protein	-
C7H56_RS02730	574793..575440	+	648	WP_106687019.1	hypothetical protein	-
C7H56_RS02735	576038..576817	-	780	WP_106687018.1	patatin-like phospholipase family protein	-
C7H56_RS02740	576884..577372	-	489	WP_106687017.1	hypothetical protein	-
C7H56_RS02745	577563..577997	-	435	WP_106687016.1	Hsp20/alpha crystallin family protein	-
C7H56_RS02750	578088..578564	-	477	WP_106687015.1	Hsp20/alpha crystallin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12257.25 Da
• Isoelectric Point: 10.2010

>T151542 WP_062623211.1 NZ_CP049774:573668-573970 [Mesoflavibacter sp. HG37]
MSKNKYRISQQAIEDLDKIWIYTLNKWSKEQADRYYDLIITEIEFIADNFMTGKSAEQTRKNYRVTKIKSHLIFYRKVEN
DIVEIVRILHQRMDIKKRLK

Nucleotide

• Length: 303 bp

>T151542 NZ_CP065607:3348686-3349084 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9306.49 Da
• Isoelectric Point: 6.8826

>AT151542 WP_028284019.1 NZ_CP049774:573429-573671 [Mesoflavibacter sp. HG37]
MGKNTSISLGNHFEDFIREEVNSGRYGSVSEVIRSALRLLEREEKKERELIKALEVGENSGFVENFDPKQHLKELHRKHL

Nucleotide

• Length: 243 bp

>AT151542 NZ_CP065607:3348390-3348683 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A137REF7

Antitoxin

• AlphaFold DB: A0A5M7B575