Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 4274..4811 Replicon plasmid unnamed1
Accession NZ_CP049754
Organism Proteus mirabilis strain PmBR607

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G9C79_RS18720 Protein ID WP_109880846.1
Coordinates 4274..4564 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag G9C79_RS18725 Protein ID WP_109880848.1
Coordinates 4551..4811 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9C79_RS18695 1..8937 - 8937 WP_152118482.1 MobA/MobL family protein -
G9C79_RS18700 554..1009 + 456 WP_109880837.1 conjugal transfer protein TraD -
G9C79_RS18705 1601..2557 + 957 WP_152118481.1 replication initiation protein -
G9C79_RS18710 2565..2990 + 426 WP_109880842.1 helix-turn-helix domain-containing protein -
G9C79_RS18715 3371..4165 + 795 WP_109880844.1 hypothetical protein -
G9C79_RS18720 4274..4564 - 291 WP_109880846.1 type II toxin-antitoxin system YafQ family toxin Toxin
G9C79_RS18725 4551..4811 - 261 WP_109880848.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G9C79_RS18730 5023..5265 + 243 WP_109880850.1 hypothetical protein -
G9C79_RS18735 5434..5921 - 488 Protein_8 restriction endonuclease subunit S -
G9C79_RS18740 5910..6421 + 512 Protein_9 winged helix-turn-helix transcriptional regulator -
G9C79_RS18745 6617..7105 - 489 WP_109880852.1 hypothetical protein -
G9C79_RS18750 7243..7323 - 81 Protein_11 restriction endonuclease subunit S -
G9C79_RS18755 7619..8203 - 585 WP_109880854.1 tRNA modification GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..8937 8937


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-69)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11268.05 Da        Isoelectric Point: 8.8769

>T151539 WP_109880846.1 NZ_CP049754:c4564-4274 [Proteus mirabilis]
MRTIKYTSAFKKDYKREKKGQHRNTVDTELQTVLELLQVDEPLPEKYRDHALVSNWVGHRDCHIKPDLVLIYKKTEEGEL
LILKLVRLGSHSELAI

Download         Length: 291 bp

>T151539 NZ_CP065607:c2994888-2994547 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9406.76 Da        Isoelectric Point: 4.4217

>AT151539 WP_109880848.1 NZ_CP049754:c4811-4551 [Proteus mirabilis]
MASNALVTTRINENIKHEATEVLATMGLTVSDAVRLLLTKVAKEKALPFDLWQPNAETITAMEEDLSKAKSFTSVKDLMA
DLNADD

Download         Length: 261 bp

>AT151539 NZ_CP065607:2994883-2994959 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References