Detailed information of TA system TA151536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1741732..1743454
• Replicon: chromosome
• Accession: NZ_CP049753
• Organism: Proteus mirabilis strain PmBR607

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: D0FZT9
• Locus tag: G9C79_RS08080
• Protein ID: WP_000356587.1
• Coordinates: 1742516..1743454 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A1U9VYW4
• Locus tag: G9C79_RS08075
• Protein ID: WP_000095578.1
• Coordinates: 1741732..1742523 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9C79_RS08045	1737405..1737686	+	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
G9C79_RS08050	1737683..1738309	+	627	WP_000667167.1	hypothetical protein	-
G9C79_RS08055	1738293..1739189	+	897	WP_032194332.1	type-F conjugative transfer system secretin TraK	-
G9C79_RS08060	1739192..1740481	+	1290	WP_049195464.1	TraB/VirB10 family protein	-
G9C79_RS08065	1740556..1741128	+	573	WP_024008834.1	type IV conjugative transfer system lipoprotein TraV	-
G9C79_RS08070	1741125..1741511	+	387	WP_000180225.1	hypothetical protein	-
G9C79_RS08075	1741732..1742523	+	792	WP_000095578.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
G9C79_RS08080	1742516..1743454	+	939	WP_000356587.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
G9C79_RS08085	1743586..1744278	+	693	WP_024008832.1	DsbC family protein	-
G9C79_RS08090	1744278..1746677	+	2400	WP_024008831.1	type IV secretion system protein TraC	-
G9C79_RS08095	1746670..1747017	+	348	WP_024008830.1	hypothetical protein	-
G9C79_RS08100	1747001..1747513	+	513	WP_024008829.1	S26 family signal peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J)	htpB	1622203..1832522	210319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35548.82 Da
• Isoelectric Point: 4.9081

>T151536 WP_000356587.1 NZ_CP049753:1742516-1743454 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T151536 NZ_CP065607:2738329-2738502 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30095.47 Da
• Isoelectric Point: 9.5097

>AT151536 WP_000095578.1 NZ_CP049753:1741732-1742523 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT151536 NZ_CP065607:2738005-2738301 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A1U9VZ44

Antitoxin

• AlphaFold DB: A0A1U9VYW4