Detailed information of TA system TA151534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapXD/-
• Location: 1704767..1705237
• Replicon: chromosome
• Accession: NZ_CP049753
• Organism: Proteus mirabilis strain PmBR607

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: A0A8E4FU70
• Locus tag: G9C79_RS07905
• Protein ID: WP_060555119.1
• Coordinates: 1704767..1705045 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: VapX
• Uniprot ID: A0A8E4FTC4
• Locus tag: G9C79_RS07910
• Protein ID: WP_060555126.1
• Coordinates: 1705049..1705237 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9C79_RS07875	1700573..1701091	+	519	WP_060555115.1	ClbS/DfsB family four-helix bundle protein	-
G9C79_RS07880	1701560..1702183	+	624	WP_060555116.1	ParA family protein	-
G9C79_RS07885	1702180..1702386	+	207	WP_060555117.1	hypothetical protein	-
G9C79_RS07890	1702436..1702543	+	108	Protein_1518	transposase	-
G9C79_RS07895	1702537..1702611	+	75	Protein_1519	IS200/IS605 family transposase	-
G9C79_RS07900	1702798..1704288	-	1491	WP_060555118.1	YadA-like family protein	-
G9C79_RS07905	1704767..1705045	-	279	WP_060555119.1	virulence factor	Toxin
G9C79_RS07910	1705049..1705237	-	189	WP_060555126.1	DUF5397 family protein	Antitoxin
G9C79_RS07915	1705358..1705657	-	300	WP_060555120.1	XRE family transcriptional regulator	-
G9C79_RS07920	1705657..1706004	-	348	WP_060555121.1	type II toxin-antitoxin system RelE/ParE family toxin	-
G9C79_RS07925	1706454..1706702	+	249	WP_060555122.1	DUF883 family protein	-
G9C79_RS07930	1706774..1707127	+	354	WP_060555123.1	hypothetical protein	-
G9C79_RS07935	1707209..1707610	+	402	WP_060555124.1	phage holin family protein	-
G9C79_RS07940	1708027..1708428	-	402	WP_049218678.1	PPC domain-containing protein	-
G9C79_RS07945	1708730..1709929	+	1200	WP_049218680.1	lipoprotein-releasing ABC transporter permease subunit LolC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J)	htpB	1622203..1832522	210319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-86)

Antitoxin

• Protein of unknown function DUF5397 (5-62)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10589.85 Da
• Isoelectric Point: 6.4606

>T151534 WP_060555119.1 NZ_CP049753:c1705045-1704767 [Proteus mirabilis]
MYAISFDLTVADTEKHHPKGVSQAYNDISSTLKRYGFERIQGSLYTNSDENMANLFQAMNALKALEWFPNSVRDIRAFRI
EQWSDFTSSMKG

Nucleotide

• Length: 279 bp

>T151534 NZ_CP065607:c1888307-1887780 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6787.78 Da
• Isoelectric Point: 3.9020

>AT151534 WP_060555126.1 NZ_CP049753:c1705237-1705049 [Proteus mirabilis]
MNTVQIPTGSIKTFGLFGIPYEVGEPAQELPDGDILVNIILVQTGEKELYKLSKLLQDPDAE

Nucleotide

• Length: 189 bp

>AT151534 NZ_CP065607:c1888580-1888314 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA