Detailed information of TA system TA151533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 1359267..1359966
• Replicon: chromosome
• Accession: NZ_CP049753
• Organism: Proteus mirabilis strain PmBR607

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: G9C79_RS06340
• Protein ID: WP_004249093.1
• Coordinates: 1359580..1359966 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: G9C79_RS06335
• Protein ID: WP_004246828.1
• Coordinates: 1359267..1359587 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9C79_RS06305	1354395..1354670	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
G9C79_RS06310	1354725..1355348	-	624	WP_004246821.1	guanylate kinase	-
G9C79_RS06315	1355650..1356267	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
G9C79_RS06320	1356404..1357690	+	1287	WP_017628657.1	DUF3748 domain-containing protein	-
G9C79_RS06325	1357907..1358791	+	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
G9C79_RS06330	1358784..1359218	+	435	WP_004246827.1	hypothetical protein	-
G9C79_RS06335	1359267..1359587	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
G9C79_RS06340	1359580..1359966	-	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G9C79_RS06345	1360128..1362200	-	2073	WP_004246830.1	glycine--tRNA ligase subunit beta	-
G9C79_RS06350	1362210..1363115	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
G9C79_RS06355	1363366..1363947	+	582	WP_049198882.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T151533 WP_004249093.1 NZ_CP049753:c1359966-1359580 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T151533 NZ_CP065607:1839191-1839676 [Escherichia coli]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT151533 WP_004246828.1 NZ_CP049753:c1359587-1359267 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT151533 NZ_CP065607:1838922-1839200 [Escherichia coli]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97