Detailed information of TA system TA151532

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1019462..1021033
• Replicon: chromosome
• Accession: NZ_CP049753
• Organism: Proteus mirabilis strain PmBR607

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B4F0T8
• Locus tag: G9C79_RS04770
• Protein ID: WP_012368637.1
• Coordinates: 1019720..1021033 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: G9C79_RS04765
• Protein ID: WP_004249771.1
• Coordinates: 1019462..1019719 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9C79_RS04735	1014680..1015027	+	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-
G9C79_RS04740	1015021..1015860	+	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
G9C79_RS04745	1015988..1016488	+	501	WP_000376623.1	GNAT family N-acetyltransferase	-
G9C79_RS04750	1016809..1016877	+	69	Protein_904	EAL domain-containing protein	-
G9C79_RS04755	1016995..1017759	+	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
G9C79_RS04760	1018104..1019138	-	1035	WP_001143643.1	DUF4365 domain-containing protein	-
G9C79_RS04765	1019462..1019719	+	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
G9C79_RS04770	1019720..1021033	+	1314	WP_012368637.1	type II toxin-antitoxin system HipA family toxin	Toxin
G9C79_RS04775	1021436..1021900	+	465	WP_004249773.1	DUF1097 domain-containing protein	-
G9C79_RS04780	1022085..1023014	+	930	WP_004246518.1	metallophosphoesterase	-
G9C79_RS04785	1023046..1025007	+	1962	WP_036919429.1	hypothetical protein	-
G9C79_RS04790	1025061..1025864	-	804	WP_004249775.1	energy transducer TonB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49670.78 Da
• Isoelectric Point: 6.5023

>T151532 WP_012368637.1 NZ_CP049753:1019720-1021033 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T151532 NZ_CP065607:1588435-1588899 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT151532 WP_004249771.1 NZ_CP049753:1019462-1019719 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT151532 NZ_CP065607:1588100-1588435 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: B4F0T8

Antitoxin

• AlphaFold DB: B4F0T9