Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 959331..959932 Replicon chromosome
Accession NZ_CP049753
Organism Proteus mirabilis strain PmBR607

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag G9C79_RS04485 Protein ID WP_004246497.1
Coordinates 959549..959932 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag G9C79_RS04480 Protein ID WP_004246496.1
Coordinates 959331..959552 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9C79_RS04455 955152..955610 + 459 WP_004246490.1 dUTP diphosphatase -
G9C79_RS04460 955730..956335 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
G9C79_RS04465 956654..957298 - 645 WP_004246493.1 orotate phosphoribosyltransferase -
G9C79_RS04470 957380..958096 - 717 WP_004249760.1 ribonuclease PH -
G9C79_RS04475 958223..959086 + 864 WP_004249947.1 YicC family protein -
G9C79_RS04480 959331..959552 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G9C79_RS04485 959549..959932 + 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
G9C79_RS04490 960340..960654 + 315 WP_004246498.1 helix-turn-helix domain-containing protein -
G9C79_RS04495 960667..961905 + 1239 WP_017628714.1 HipA domain-containing protein -
G9C79_RS04500 962262..963161 - 900 WP_017628715.1 N-acetylmuramic acid 6-phosphate etherase -
G9C79_RS04505 963270..964007 + 738 WP_004249950.1 sel1 repeat family protein -
G9C79_RS04510 964103..964561 - 459 WP_152118399.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 950000..961905 11905


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T151531 WP_004246497.1 NZ_CP049753:959549-959932 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T151531 NZ_CP065607:c1546060-1545746 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT151531 WP_004246496.1 NZ_CP049753:959331-959552 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT151531 NZ_CP065607:c1545749-1545333 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References