Detailed information of TA system TA151526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2459098..2460011
• Replicon: chromosome
• Accession: NZ_CP049752
• Organism: Raoultella ornithinolytica strain WM1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: G7Z36_RS11555
• Protein ID: WP_165551757.1
• Coordinates: 2459098..2459571 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A808Y7A4
• Locus tag: G7Z36_RS11560
• Protein ID: WP_004862777.1
• Coordinates: 2459568..2460011 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7Z36_RS11530	2455137..2455745	-	609	WP_069475887.1	glutathione S-transferase family protein	-
G7Z36_RS11535	2455987..2456892	+	906	WP_032716408.1	transcriptional regulator GcvA	-
G7Z36_RS11540	2456920..2457825	-	906	WP_044349852.1	LysR family transcriptional regulator	-
G7Z36_RS11545	2457928..2458245	+	318	WP_004862785.1	nuclear transport factor 2 family protein	-
G7Z36_RS11550	2458238..2459017	+	780	WP_004862782.1	SDR family oxidoreductase	-
G7Z36_RS11555	2459098..2459571	-	474	WP_165551757.1	RES domain-containing protein	Toxin
G7Z36_RS11560	2459568..2460011	-	444	WP_004862777.1	DUF2384 domain-containing protein	Antitoxin
G7Z36_RS11565	2460201..2460767	-	567	WP_015584190.1	DJ-1/PfpI family protein	-
G7Z36_RS11570	2461165..2461947	+	783	WP_032717546.1	DUF3750 domain-containing protein	-
G7Z36_RS11575	2462143..2463366	+	1224	WP_160873155.1	zinc metallochaperone GTPase ZigA	-
G7Z36_RS11595	2464296..2464772	-	477	WP_071887178.1	acid resistance repetitive basic protein Asr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17493.81 Da
• Isoelectric Point: 5.5449

>T151526 WP_165551757.1 NZ_CP049752:c2459571-2459098 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPNSEVESLDKQ
WLPDNRQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Nucleotide

• Length: 474 bp

>T151526 NZ_CP065607:c41983-41880 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16190.45 Da
• Isoelectric Point: 4.9405

>AT151526 WP_004862777.1 NZ_CP049752:c2460011-2459568 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT151526 NZ_CP065607:41879-42113 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: A0A808Y7A4