Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 895447..896104 Replicon chromosome
Accession NZ_CP049752
Organism Raoultella ornithinolytica strain WM1

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag G7Z36_RS04405 Protein ID WP_004867355.1
Coordinates 895694..896104 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag G7Z36_RS04400 Protein ID WP_004867358.1
Coordinates 895447..895713 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Z36_RS04375 890582..892015 - 1434 WP_004867372.1 6-phospho-beta-glucosidase -
G7Z36_RS04380 892135..892863 - 729 WP_004867368.1 MurR/RpiR family transcriptional regulator -
G7Z36_RS04385 892913..893224 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
G7Z36_RS04390 893386..894045 + 660 WP_004867362.1 hemolysin III family protein -
G7Z36_RS04395 894167..895150 - 984 WP_015585783.1 tRNA-modifying protein YgfZ -
G7Z36_RS04400 895447..895713 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
G7Z36_RS04405 895694..896104 + 411 WP_004867355.1 protein YgfX Toxin
G7Z36_RS04410 896112..896633 - 522 WP_004867353.1 flavodoxin FldB -
G7Z36_RS04415 896812..897708 + 897 WP_054829218.1 site-specific tyrosine recombinase XerD -
G7Z36_RS04420 897731..898444 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G7Z36_RS04425 898450..900183 + 1734 WP_015585785.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T151517 WP_004867355.1 NZ_CP049752:895694-896104 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T151517 NZ_CP065604:118934-119230 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCGGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGTTTCTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT151517 WP_004867358.1 NZ_CP049752:895447-895713 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT151517 NZ_CP065604:118638-118937 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATAAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCCTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References